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Nitroreductase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1f5v ]], [[1oo5]] – EcNR – ''Escherichia coli''<br />
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*Nitroreductase
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[[3bm1]], [[1ds7]] – EcNR minimal<br />
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[[3bm2]] – EcNR minimal -FMN<br />
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[[1nec]], [[1kqd]] – EclNR – ''Enterobacter cloacae''<br />
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-
[[1ywq]], [[2i7h]] – NR – ''Bacillus cereus''<br />
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[[2b67]] – NR – ''Streptococcus pneumonia''<br />
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-
[[3ek3]], [[3hoi]] – NR – ''Bacterioides fragilis''<br />
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[[3g14]] – NR – ''Clostridium novyi''<br />
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-
[[3h4o]], [[3koq]] - NR – ''Clostridium difficile''<br />
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[[3gr3]] – NR – ''Bartonella henselae''<br />
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[[3hzn]] – NR – ''Salmonella typhimurium''<br />
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[[3k6h]] – NR – ''Agrobacterium tumefaciens''<br />
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-
[[2wqf]] – NR – ''Lactococcus lactis''<br />
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-
[[2wzv]], [[2ymv]] – MsNR – ''Mycobacterium smegmatis''<br />
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[[3of4]] – NR FMN/FAD – ''Idiomarina loihiensis''<br />
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-
[[3n2s]] – NR – ''Bacillus subtilis''<br />
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-
[[3pxv]] – NR – ''Desulfitobacterium hafniense''<br />
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-
[[3qdl]] – NR – ''Helicobacter pylori''<br />
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-
[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br />
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[[3r5r]], [[3r5w]] – MtNR F420
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===Nitroreductase binary complex===
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**[[1f5v ]], [[1oo5]] – EcNR – ''Escherichia coli''<br />
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**[[3bm1]], [[1ds7]] – EcNR minimal<br />
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**[[3bm2]] – EcNR minimal -FMN<br />
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**[[1nec]], [[1kqd]] – EclNR – ''Enterobacter cloacae''<br />
 +
**[[1ywq]], [[2i7h]] – NR – ''Bacillus cereus''<br />
 +
**[[2b67]] – NR – ''Streptococcus pneumonia''<br />
 +
**[[3ek3]], [[3hoi]] – NR – ''Bacterioides fragilis''<br />
 +
**[[3g14]] – NR – ''Clostridium novyi''<br />
 +
**[[3h4o]], [[3koq]] - NR – ''Clostridium difficile''<br />
 +
**[[3gr3]] – NR – ''Bartonella henselae''<br />
 +
**[[3hzn]] – NR – ''Salmonella typhimurium''<br />
 +
**[[3k6h]] – NR – ''Agrobacterium tumefaciens''<br />
 +
**[[2wqf]] – NR – ''Lactococcus lactis''<br />
 +
**[[2wzv]], [[2ymv]] – MsNR – ''Mycobacterium smegmatis''<br />
 +
**[[3of4]] – NR FMN/FAD – ''Idiomarina loihiensis''<br />
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**[[3n2s]] – NR – ''Bacillus subtilis''<br />
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**[[3pxv]] – NR – ''Desulfitobacterium hafniense''<br />
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**[[3qdl]] – NR – ''Helicobacter pylori''<br />
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**[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br />
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**[[3r5r]], [[3r5w]] – MtNR F420
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[[1kqb]] – EclNR + benzoate<br />
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*Nitroreductase binary complex
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[[1kqc]] – EclNR + acetate<br />
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[[1ylr]], [[1ylu]] - EcNR + acetate<br />
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[[1icr]], [[1icu]], [[1icv]] – EcNR + nicotinic acid<br />
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[[1ooq]] – EcNR + dicoumarol<br />
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-
[[1oo6]], [[1oon]], [[1idt]] – EcNR + benzamide derivative<br />
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-
[[1yki]] – EcNR + antibiotic<br />
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-
[[2wzw]] - MsNR + NADPH
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 +
**[[1kqb]] – EclNR + benzoate<br />
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**[[1kqc]] – EclNR + acetate<br />
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**[[1ylr]], [[1ylu]] - EcNR + acetate<br />
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**[[1icr]], [[1icu]], [[1icv]] – EcNR + nicotinic acid<br />
 +
**[[1ooq]] – EcNR + dicoumarol<br />
 +
**[[1oo6]], [[1oon]], [[1idt]] – EcNR + benzamide derivative<br />
 +
**[[1yki]] – EcNR + antibiotic<br />
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**[[2wzw]] - MsNR + NADPH
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:26, 1 December 2014

Template:STRUCTURE 1f5v

Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO2 group. The NO2 group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.

3D structures of nitroreductase

Updated on 01-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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