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Obscurin

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==3D structures of obscurin==
==3D structures of obscurin==
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[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
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{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
+
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[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
+
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[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
+
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[[2edr]] - hObs Ig domain residues 3361-3449 – NMR<BR />
+
-
[[2edt]] - hObs Ig domain residues 3449-3537 – NMR<BR />
+
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[[2edw]] - hObs I-set domain residues 3537-3630 – NMR<BR />
+
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[[2edh]] – hObs PDZ domain residues 3614-3713 – NMR<BR />
+
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[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
+
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[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
+
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[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
+
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===Obscurin-like protein 1===
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*Obscurin
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[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
+
**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
-
[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
+
**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
-
[[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain <br />
+
**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
-
[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
+
**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
 +
**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
 +
**[[2edr]] - hObs Ig domain residues 3361-3449 – NMR<BR />
 +
**[[2edt]] - hObs Ig domain residues 3449-3537 – NMR<BR />
 +
**[[2edw]] - hObs I-set domain residues 3537-3630 – NMR<BR />
 +
**[[2edh]] – hObs PDZ domain residues 3614-3713 – NMR<BR />
 +
**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
 +
**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
 +
**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
 +
*Obscurin-like protein 1
 +
 +
**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
 +
**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
 +
**[[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain <br />
 +
**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:44, 2 December 2014

Template:STRUCTURE 2yz8

Obscurin (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see Group:MUZIC:Obscurin.

3D structures of obscurin

02-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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