Pantothenate kinase
From Proteopedia
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+ | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
- | + | *'''PanK I''' | |
- | [[1esm]] – EcPanK + CoA – ''Escherichia coli''<br /> | + | **[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br /> |
- | [[1esn]] - EcPanK + ANP<br /> | + | **[[1esn]] - EcPanK + ANP<br /> |
- | [[1sq5]] - EcPanK + ADP + PAU<br /> | + | **[[1sq5]] - EcPanK + ADP + PAU<br /> |
- | [[3tqc]] - PanK – ''Coxiella burnetii'' | + | **[[3tqc]] - PanK – ''Coxiella burnetii'' |
- | + | *PanK I binary complex | |
- | [[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br /> | + | **[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br /> |
- | [[2zs8]], [[2zsb]] - MtPanK + ADP<br /> | + | **[[2zs8]], [[2zsb]] - MtPanK + ADP<br /> |
- | [[3af1]] - MtPanK + GDP <br /> | + | **[[3af1]] - MtPanK + GDP <br /> |
- | [[3af2]] - MtPanK + AMPPCP<br /> | + | **[[3af2]] - MtPanK + AMPPCP<br /> |
- | [[3af4]] - MtPanK + GMPPCP<br /> | + | **[[3af4]] - MtPanK + GMPPCP<br /> |
- | [[2zsd]] - MtPanK + CoA<br /> | + | **[[2zsd]] - MtPanK + CoA<br /> |
- | [[3avo]] - MtPanK + PAU<br /> | + | **[[3avo]] - MtPanK + PAU<br /> |
- | [[3avp]], [[3avq]] - MtPanK + PAU derivative<br /> | + | **[[3avp]], [[3avq]] - MtPanK + PAU derivative<br /> |
- | [[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br /> | + | **[[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br /> |
- | [[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br /> | + | **[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br /> |
- | + | *PanK I ternary complex | |
- | [[2zs9]] - MtPanK + ADP + PAU<br /> | + | **[[2zs9]] - MtPanK + ADP + PAU<br /> |
- | [[2zse]] - MtPanK + AMPPCP + PAU<br /> | + | **[[2zse]] - MtPanK + AMPPCP + PAU<br /> |
- | [[3af3]] - MtPanK + GMPPCP + PAU<br /> | + | **[[3af3]] - MtPanK + GMPPCP + PAU<br /> |
- | [[2zsf]] - MtPanK + ADP + ATP<br /> | + | **[[2zsf]] - MtPanK + ADP + ATP<br /> |
- | [[2zsa]] - MtPanK + ADP + PPT<BR /> | + | **[[2zsa]] - MtPanK + ADP + PPT<BR /> |
- | [[3aez]] - MtPanK + GDP + PPT<BR /> | + | **[[3aez]] - MtPanK + GDP + PPT<BR /> |
- | [[3af0]] - MtPanK + GDP + PAU<br /> | + | **[[3af0]] - MtPanK + GDP + PAU<br /> |
- | [[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br /> | + | **[[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br /> |
- | [[4gi7]] – KpPanK + ADP + pantothenate analog<br /> | + | **[[4gi7]] – KpPanK + ADP + pantothenate analog<br /> |
- | + | *'''PanK II''' | |
- | [[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> | + | **[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> |
- | [[4nb4]] - SaPanK + ADP + pantothenamide<br /> | + | **[[4nb4]] - SaPanK + ADP + pantothenamide<br /> |
- | + | *'''PanK III''' | |
- | [[2gtd]] - TmPanK – ''Thermotoga maritima''<br /> | + | **[[2gtd]] - TmPanK – ''Thermotoga maritima''<br /> |
- | [[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br /> | + | **[[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br /> |
- | [[2h3g]] - PanK – ''Bacillus anthracis''<br /> | + | **[[2h3g]] - PanK – ''Bacillus anthracis''<br /> |
- | [[3djc]] - PanK – ''Legionella pneumophila''<br /> | + | **[[3djc]] - PanK – ''Legionella pneumophila''<br /> |
- | [[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br /> | + | **[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br /> |
- | + | *PanK III binary complex | |
- | [[2f9w]] - PaPanK + PAU<br /> | + | **[[2f9w]] - PaPanK + PAU<br /> |
- | [[3bex]] - TmPanK + PAU<br /> | + | **[[3bex]] - TmPanK + PAU<br /> |
- | [[3bf3]] - TmPanK + PPT<BR /> | + | **[[3bf3]] - TmPanK + PPT<BR /> |
- | + | *PanK III ternary complex | |
- | [[3bf1]] - TmPanK + ADP + PAU<br /> | + | **[[3bf1]] - TmPanK + ADP + PAU<br /> |
- | [[4o5f]] - BtPanK + ADP + PAU <br /> | + | **[[4o5f]] - BtPanK + ADP + PAU <br /> |
- | + | *'''Human PanK''' | |
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+ | **[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br /> | ||
+ | **[[2i7p]], [[3mk6]] - hPanK 3 + CoA<br /> | ||
+ | **[[3sms]] – hPanK 3 + PAU analog | ||
+ | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] |
Revision as of 08:41, 2 December 2014
Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.
3D structures of pantothenate kinase
Updated on 02-December-2014