Phosphoenolpyruvate carboxykinase

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{{STRUCTURE_2olr| PDB=2olr | SIZE=350| SCENE= |right|CAPTION=ATP-driven E. coli PEPCK complex with ATP (stick model), CO2 and Mg+2 ion (green) [[2olr]] }}
{{STRUCTURE_2olr| PDB=2olr | SIZE=350| SCENE= |right|CAPTION=ATP-driven E. coli PEPCK complex with ATP (stick model), CO2 and Mg+2 ion (green) [[2olr]] }}
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===PEPCK ATP driven===
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*Phosphoenolpyruvate carboxykinase ATP driven
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[[1oen]], [[1fiy]] – EcPEPCK - ''Escherichia coli''<br />
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**[[1oen]], [[1fiy]] – EcPEPCK - ''Escherichia coli''<br />
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[[1ayl]] – EcPEPCK + ATP + oxalate + Mg<br />
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**[[1ayl]] – EcPEPCK + ATP + oxalate + Mg<br />
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[[1aq2]] – EcPEPCK + ATP + pyruvate + Mg + Mn<br />
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**[[1aq2]] – EcPEPCK + ATP + pyruvate + Mg + Mn<br />
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[[2py7]] – EcPEPCK (mutant) + ATP + Mg + Mn<br />
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**[[2py7]] – EcPEPCK (mutant) + ATP + Mg + Mn<br />
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[[2olq]] – EcPEPCK + ATP + CO2 + Mg + Mn<br />
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**[[2olq]] – EcPEPCK + ATP + CO2 + Mg + Mn<br />
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[[2pxz]] – EcPEPCK + ATP + CO2 + oxaloacetate + Mg + Mn<br />
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**[[2pxz]] – EcPEPCK + ATP + CO2 + oxaloacetate + Mg + Mn<br />
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[[2olr]] – EcPEPCK + ATP + CO2 + Mg <br />
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**[[2olr]] – EcPEPCK + ATP + CO2 + Mg <br />
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[[1os1]] – EcPEPCK + ATP + pyruvate + Mg + Ca<br />
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**[[1os1]] – EcPEPCK + ATP + pyruvate + Mg + Ca<br />
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[[1k3c]] – EcPEPCK + ADP + pyruvate + Mg + AlF3<br />
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**[[1k3c]] – EcPEPCK + ADP + pyruvate + Mg + AlF3<br />
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[[1k3d]] – EcPEPCK + ADP + Mg + AlF3<br />
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**[[1k3d]] – EcPEPCK + ADP + Mg + AlF3<br />
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[[1j3b]] – TtPEPCK – ''Thermus thermophilus'' <br />
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**[[1j3b]] – TtPEPCK – ''Thermus thermophilus'' <br />
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[[1yvy]] – AnsPEPCK – ''Anaerobiospirillum succiniciproducens''<br />
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**[[1yvy]] – AnsPEPCK – ''Anaerobiospirillum succiniciproducens''<br />
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[[1ytm]] – AnsPEPCK + ATP + oxalate + Mg + Mn<br />
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**[[1ytm]] – AnsPEPCK + ATP + oxalate + Mg + Mn<br />
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[[1xkv]], [[2pc9]] – TtPEPCK + ATP <br />
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**[[1xkv]], [[2pc9]] – TtPEPCK + ATP <br />
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===PEPCK GTP driven===
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*Phosphoenolpyruvate carboxykinase GTP driven
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[[1khb]] – EcPEPCK + GTP analog + Mg <br />
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**[[1khb]] – EcPEPCK + GTP analog + Mg <br />
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[[1khe]] – EcPEPCK + GTP analog + Mn <br />
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**[[1khe]] – EcPEPCK + GTP analog + Mn <br />
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[[1khf]] – EcPEPCK + PEP + Mn <br />
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**[[1khf]] – EcPEPCK + PEP + Mn <br />
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[[1khg]] – EcPEPCK + Mn <br />
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**[[1khg]] – EcPEPCK + Mn <br />
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[[1m51]], [[1nhx]] – EcPEPCK + inhibitor + Mn<br />
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**[[1m51]], [[1nhx]] – EcPEPCK + inhibitor + Mn<br />
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[[2faf]] – cPEPCK + Mn - chicken<br />
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**[[2faf]] – cPEPCK + Mn - chicken<br />
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[[2fah]] – cPEPCK + GDP + Mn <br />
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**[[2fah]] – cPEPCK + GDP + Mn <br />
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[[2qzy]] – cPEPCK + PEP + Mn <br />
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**[[2qzy]] – cPEPCK + PEP + Mn <br />
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[[2gmv]] – hPEPCK + inhibitor + PEP + Mn - human<br />
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**[[2gmv]] – hPEPCK + inhibitor + PEP + Mn - human<br />
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[[2qew]] – rPEPCK + Mn - rat<br />
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**[[2qew]] – rPEPCK + Mn - rat<br />
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[[2qey]] – rPEPCK + GTP + Mn<br />
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**[[2qey]] – rPEPCK + GTP + Mn<br />
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[[2qf1]] – rPEPCK + oxaloacetate + Mn<br />
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**[[2qf1]] – rPEPCK + oxaloacetate + Mn<br />
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[[2rk7]] – rPEPCK + oxalate + Mn<br />
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**[[2rk7]] – rPEPCK + oxalate + Mn<br />
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[[4gnm]], [[4gnq]] - rPEPCK + oxalate + GTP + Mn<br />
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**[[4gnm]], [[4gnq]] - rPEPCK + oxalate + GTP + Mn<br />
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[[4gmw]], [[4gnl]], [[4gnp]] – rPEPCK + PEP + GDP + Mn <br />
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**[[4gmw]], [[4gnl]], [[4gnp]] – rPEPCK + PEP + GDP + Mn <br />
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[[3dt2]], [[3dt4]], [[4gmu]] – rPEPCK + GTP + oxalate + Mn<br />
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**[[3dt2]], [[3dt4]], [[4gmu]] – rPEPCK + GTP + oxalate + Mn<br />
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[[3mof]] – rPEPCK (mutant) + GTP + oxalate + Mn<br />
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**[[3mof]] – rPEPCK (mutant) + GTP + oxalate + Mn<br />
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[[3dt7]], [[4gmm]], [[4gmz]], [[4gno]] – rPEPCK + GTP + sulfopyruvate + Mn<br />
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**[[3dt7]], [[4gmm]], [[4gmz]], [[4gno]] – rPEPCK + GTP + sulfopyruvate + Mn<br />
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[[3moe]] – rPEPCK (mutant) + GTP + sulfopyruvate + Mn<br />
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**[[3moe]] – rPEPCK (mutant) + GTP + sulfopyruvate + Mn<br />
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[[3dtb]] – rPEPCK + GTP + phosphoglycolate + Mn<br />
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**[[3dtb]] – rPEPCK + GTP + phosphoglycolate + Mn<br />
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[[3moh]] – rPEPCK (mutant) + GDP + phosphoglycolate + Mn<br />
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**[[3moh]] – rPEPCK (mutant) + GDP + phosphoglycolate + Mn<br />
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[[2rk8]], [[2rka]], [[2rkd]], [[2rke]] – rPEPCK + inhibitor + Mn<br />
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**[[2rk8]], [[2rka]], [[2rkd]], [[2rke]] – rPEPCK + inhibitor + Mn<br />
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[[2qf2]] – rPEPCK + GDP + oxaloacetate + Mn<br />
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**[[2qf2]] – rPEPCK + GDP + oxaloacetate + Mn<br />
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[[2zci]] – PEPCK – ''Corynebacterium glutamicum'' <br />
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*Phosphoenolpyruvate carboxykinase
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[[1ygg]] – AsPEPCK – ''Actinobacillus succinogenes''<br />
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[[1ylh]] – AsPEPCK + pyruvate + Mn<br />
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[[1ii2]] – PEPCK – ''Trypanosoma cruzi''<br />
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**[[2zci]] – PEPCK – ''Corynebacterium glutamicum'' <br />
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**[[1ygg]] – AsPEPCK – ''Actinobacillus succinogenes''<br />
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**[[1ylh]] – AsPEPCK + pyruvate + Mn<br />
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**[[1ii2]] – PEPCK – ''Trypanosoma cruzi''<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:38, 3 December 2014

Template:STRUCTURE 2olr

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO2. PEPCK is part of the gluconeogenesis pathway. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate.

3D Structures of PEPCK

Updated on 03-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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