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3gb8

From Proteopedia

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[[Image:3gb8.png|left|200px]]
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==Crystal structure of CRM1/Snurportin-1 complex==
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<StructureSection load='3gb8' size='340' side='right' caption='[[3gb8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GB8 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRM1, XPO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RNUT1, SNUPN, SPN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gb8 RCSB], [http://www.ebi.ac.uk/pdbsum/3gb8 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gb8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CRM1 (also known as XPO1 and exportin 1) mediates nuclear export of hundreds of proteins through the recognition of the leucine-rich nuclear export signal (LR-NES). Here we present the 2.9 A structure of CRM1 bound to snurportin 1 (SNUPN). Snurportin 1 binds CRM1 in a bipartite manner by means of an amino-terminal LR-NES and its nucleotide-binding domain. The LR-NES is a combined alpha-helical-extended structure that occupies a hydrophobic groove between two CRM1 outer helices. The LR-NES interface explains the consensus hydrophobic pattern, preference for intervening electronegative residues and inhibition by leptomycin B. The second nuclear export signal epitope is a basic surface on the snurportin 1 nucleotide-binding domain, which binds an acidic patch on CRM1 adjacent to the LR-NES site. Multipartite recognition of individually weak nuclear export signal epitopes may be common to CRM1 substrates, enhancing CRM1 binding beyond the generally low affinity LR-NES. Similar energetic construction is also used in multipartite nuclear localization signals to provide broad substrate specificity and rapid evolution in nuclear transport.
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{{STRUCTURE_3gb8| PDB=3gb8 | SCENE= }}
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Structural basis for leucine-rich nuclear export signal recognition by CRM1.,Dong X, Biswas A, Suel KE, Jackson LK, Martinez R, Gu H, Chook YM Nature. 2009 Apr 30;458(7242):1136-41. Epub 2009 Apr 1. PMID:19339969<ref>PMID:19339969</ref>
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===Crystal structure of CRM1/Snurportin-1 complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19339969}}
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==See Also==
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*[[Exportin|Exportin]]
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==About this Structure==
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== References ==
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[[3gb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GB8 OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:019339969</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Biswas, A.]]
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[[Category: Biswas, A]]
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[[Category: Chook, Y M.]]
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[[Category: Chook, Y M]]
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[[Category: Dong, X.]]
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[[Category: Dong, X]]
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[[Category: Gu, H.]]
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[[Category: Gu, H]]
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[[Category: Jackson, L K.]]
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[[Category: Jackson, L K]]
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[[Category: Martinez, R.]]
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[[Category: Martinez, R]]
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[[Category: Suel, K E.]]
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[[Category: Suel, K E]]
[[Category: Host-virus interaction]]
[[Category: Host-virus interaction]]
[[Category: Mrna transport]]
[[Category: Mrna transport]]

Revision as of 10:04, 3 December 2014

Crystal structure of CRM1/Snurportin-1 complex

3gb8, resolution 2.90Å

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