3g40

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3g40" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3g40.png|left|200px]]
+
==Crystal structure of the cytoplasmic domain of a prokaryotic cation chloride cotransporter==
 +
<StructureSection load='3g40' size='340' side='right' caption='[[3g40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3g40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G40 FirstGlance]. <br>
 +
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MA4506 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2214 Methanosarcina acetivorans])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g40 RCSB], [http://www.ebi.ac.uk/pdbsum/3g40 PDBsum]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g40_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride in dependence of sodium and potassium. The proteins share a conserved structural scaffold that consists of a transmembrane transport domain followed by a cytoplasmic regulatory domain. We have determined the X-ray structure of the C-terminal domain of the archaea Methanosarcina acetivorans. The structure shows a novel fold of a regulatory domain that is distantly related to universal stress proteins. The protein forms dimers in solution, which is consistent with the proposed dimeric organization of eukaryotic CCC transporters. The dimer interface observed in different crystal forms is unusual because the buried area is relatively small and hydrophilic. By using a biochemical approach we show that this interaction is preserved in solution and in the context of the full-length transporter. Our studies reveal structural insight into the CCC family and establish the oligomeric organization of this important class of transport proteins.
-
{{STRUCTURE_3g40| PDB=3g40 | SCENE= }}
+
X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter.,Warmuth S, Zimmermann I, Dutzler R Structure. 2009 Apr 15;17(4):538-46. PMID:19368887<ref>PMID:19368887</ref>
-
===Crystal structure of the cytoplasmic domain of a prokaryotic cation chloride cotransporter===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_19368887}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[3g40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G40 OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:019368887</ref><references group="xtra"/>
+
[[Category: Methanosarcina acetivorans]]
[[Category: Methanosarcina acetivorans]]
-
[[Category: Dutzler, R.]]
+
[[Category: Dutzler, R]]
-
[[Category: Warmuth, S.]]
+
[[Category: Warmuth, S]]
-
[[Category: Zimmermann, I.]]
+
[[Category: Zimmermann, I]]
[[Category: Alpha/beta fold 10-stranded twisted beta sheet]]
[[Category: Alpha/beta fold 10-stranded twisted beta sheet]]
[[Category: Transport protein]]
[[Category: Transport protein]]

Revision as of 10:10, 3 December 2014

Crystal structure of the cytoplasmic domain of a prokaryotic cation chloride cotransporter

3g40, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3g40"
Personal tools