1n4x

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[[Image:1n4x.jpg|left|200px]]<br /><applet load="1n4x" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1n4x.jpg|left|200px]]
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caption="1n4x, resolution 1.7&Aring;" />
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'''Structure of scFv 1696 at acidic pH'''<br />
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{{Structure
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|PDB= 1n4x |SIZE=350|CAPTION= <scene name='initialview01'>1n4x</scene>, resolution 1.7&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of scFv 1696 at acidic pH'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1N4X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4X OCA].
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1N4X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4X OCA].
==Reference==
==Reference==
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Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases., Lescar J, Brynda J, Fabry M, Horejsi M, Rezacova P, Sedlacek J, Bentley GA, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):955-7. Epub 2003, Apr 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12777823 12777823]
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Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases., Lescar J, Brynda J, Fabry M, Horejsi M, Rezacova P, Sedlacek J, Bentley GA, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):955-7. Epub 2003, Apr 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12777823 12777823]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: immunoglobulin]]
[[Category: immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:02:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:52:13 2008''

Revision as of 10:52, 20 March 2008

Image:1n4x.jpg


PDB ID 1n4x

Drag the structure with the mouse to rotate
, resolution 1.7Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Structure of scFv 1696 at acidic pH


Overview

The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of 1696 (scFv-1696) in the non-complexed form, solved at 1.7 A resolution, is compared with the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures.

About this Structure

1N4X is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases., Lescar J, Brynda J, Fabry M, Horejsi M, Rezacova P, Sedlacek J, Bentley GA, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):955-7. Epub 2003, Apr 25. PMID:12777823

Page seeded by OCA on Thu Mar 20 12:52:13 2008

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