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4e13
From Proteopedia
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| - | [[ | + | ==Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase== |
| + | <StructureSection load='4e13' size='340' side='right' caption='[[4e13]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4e13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baylyi Acinetobacter baylyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E13 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dyd|4dyd]], [[4e12|4e12]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e13 RCSB], [http://www.ebi.ac.uk/pdbsum/4e13 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product. | ||
| - | + | Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase.,Lu M, Huang Y, White MA, Wu X, Liu N, Cheng X, Chen Y Chem Commun (Camb). 2012 Oct 24;48(92):11352-4. doi: 10.1039/c2cc36334h. PMID:23073461<ref>PMID:23073461</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Acinetobacter baylyi]] | [[Category: Acinetobacter baylyi]] | ||
| - | [[Category: Chen, Y | + | [[Category: Chen, Y]] |
| - | [[Category: Cheng, X | + | [[Category: Cheng, X]] |
| - | [[Category: Huang, Y | + | [[Category: Huang, Y]] |
| - | [[Category: Liu, N | + | [[Category: Liu, N]] |
| - | [[Category: Lu, M | + | [[Category: Lu, M]] |
| - | [[Category: White, M A | + | [[Category: White, M A]] |
| - | [[Category: Wu, X | + | [[Category: Wu, X]] |
[[Category: Nadh]] | [[Category: Nadh]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 16:59, 9 December 2014
Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase
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Categories: Acinetobacter baylyi | Chen, Y | Cheng, X | Huang, Y | Liu, N | Lu, M | White, M A | Wu, X | Nadh | Oxidoreductase
