This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3v0v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3v0v.png|left|200px]]
+
==Fab WN1 222-5 unliganded==
 +
<StructureSection load='3v0v' size='340' side='right' caption='[[3v0v]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3v0v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V0V FirstGlance]. <br>
 +
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v0w|3v0w]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v0v RCSB], [http://www.ebi.ac.uk/pdbsum/3v0v PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Escherichia coli infections, a leading cause of septic shock, remain a major threat to human health because of the fatal action to endotoxin (LPS). Therapeutic attempts to neutralize endotoxin currently focus on inhibiting the interaction of the toxic component lipid A with myeloid differentiating factor 2, which forms a trimeric complex together with Toll-like receptor 4 to induce immune cell activation. The 1.73-A resolution structure of the unique endotoxin-neutralizing protective antibody WN1 222-5 in complex with the core region shows that it recognizes LPS of all E. coli serovars in a manner similar to Toll-like receptor 4, revealing that protection can be achieved by targeting the inner core of LPS and that recognition of lipid A is not required. Such interference with Toll-like receptor complex formation opens new paths for antibody sepsis therapy independent of lipid A antagonists.
-
{{STRUCTURE_3v0v| PDB=3v0v | SCENE= }}
+
Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.,Gomery K, Muller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20877-82. doi:, 10.1073/pnas.1209253109. Epub 2012 Nov 26. PMID:23184990<ref>PMID:23184990</ref>
-
===Fab WN1 222-5 unliganded===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_23184990}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[3v0v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0V OCA].
+
</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Evans, S V.]]
+
[[Category: Evans, S V]]
-
[[Category: Gomery, K.]]
+
[[Category: Gomery, K]]
[[Category: Antibody]]
[[Category: Antibody]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: Fab]]
[[Category: Fab]]
[[Category: Immune system]]
[[Category: Immune system]]

Revision as of 17:28, 9 December 2014

Fab WN1 222-5 unliganded

3v0v, resolution 2.13Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3v0v"
Personal tools