1oay

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1oay.jpg|left|200px]]<br /><applet load="1oay" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1oay.jpg|left|200px]]
-
caption="1oay, resolution 2.66&Aring;" />
+
 
-
'''ANTIBODY MULTISPECIFICITY MEDIATED BY CONFORMATIONAL DIVERSITY'''<br />
+
{{Structure
 +
|PDB= 1oay |SIZE=350|CAPTION= <scene name='initialview01'>1oay</scene>, resolution 2.66&Aring;
 +
|SITE= <scene name='pdbsite=AC1:Fur+Binding+Site+For+Chain+J'>AC1</scene>
 +
|LIGAND= <scene name='pdbligand=FUR:ACENAPHTHENEQUINONE'>FUR</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''ANTIBODY MULTISPECIFICITY MEDIATED BY CONFORMATIONAL DIVERSITY'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1OAY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus] with <scene name='pdbligand=FUR:'>FUR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Fur+Binding+Site+For+Chain+J'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAY OCA].
+
1OAY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAY OCA].
==Reference==
==Reference==
-
Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12610298 12610298]
+
Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12610298 12610298]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Rattus rattus]]
[[Category: Rattus rattus]]
Line 23: Line 32:
[[Category: multispecificity]]
[[Category: multispecificity]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:15:33 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:08:17 2008''

Revision as of 11:08, 20 March 2008

Image:1oay.jpg


PDB ID 1oay

Drag the structure with the mouse to rotate
, resolution 2.66Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



ANTIBODY MULTISPECIFICITY MEDIATED BY CONFORMATIONAL DIVERSITY


Overview

A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.

About this Structure

1OAY is a Protein complex structure of sequences from Rattus rattus. Full crystallographic information is available from OCA.

Reference

Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298

Page seeded by OCA on Thu Mar 20 13:08:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oay"
Personal tools