Single-stranded DNA-binding protein

(Difference between revisions)

Revision as of 10:38, 10 December 2014

Single-stranded DNA-binding protein (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities. Viral SSB proteins are monomeric while eukaryotic SSB (Replication protein A – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD). The mitochondrial human SSB (HsmtSSB) is a homotetramer. See also Single stranded binding protein.

3D Structures of single-stranded DNA-binding protein

Updated on 10-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-===SSB===
+*Single-stranded DNA-binding protein
-[[1gpc]] – SSB gp32 – Enterobacteria phage T4 <br />
+**[[1gpc]] – SSB gp32 – Enterobacteria phage T4 <br />
-[[2a1k]] – SSB gp32 – Enterobacteria phage RB69 <br />
+**[[2a1k]] – SSB gp32 – Enterobacteria phage RB69 <br />
-[[1je5]] – SSB – Enterobacteria phage T7 <br />
+**[[1je5]] – SSB – Enterobacteria phage T7 <br />
-[[1adu]], [[1adv]], [[1anv]] – SSB C terminal – human adenovirus 5 <br />
+**[[1adu]], [[1adv]], [[1anv]] – SSB C terminal – human adenovirus 5 <br />
-[[1urj]] – SSB – human herpesvirus 1 <br />
+**[[1urj]] – SSB – human herpesvirus 1 <br />
-[[1pfs]] – SSB (mutant) – Pseudomonas phage PF3 - NMR<br />
+**[[1pfs]] – SSB (mutant) – Pseudomonas phage PF3 - NMR<br />
-[[3ull]], [[1s3o]], [[2dud]] – HsmtSSB residues 16-148 – human <br />
+**[[3ull]], [[1s3o]], [[2dud]] – HsmtSSB residues 16-148 – human <br />
-[[1kaw]] – EcSSB chymotryptic domain – ''Escherichia coli'' <br />
+**[[1kaw]] – EcSSB chymotryptic domain – ''Escherichia coli'' <br />
-[[1qvc]], [[1sru]] – EcSSB  <br />
+**[[1qvc]], [[1sru]] – EcSSB  <br />
-[[1o7i]] – SSB residues 1-119 – ''Sulfolobus solfataricus''<br />
+**[[1o7i]] – SSB residues 1-119 – ''Sulfolobus solfataricus''<br />
-[[1ue1]], [[1ue5]], [[1ue7]], [[1ue6]] – SSB – ''Mycobacterium tuberculosis'' <br />
+**[[1ue1]], [[1ue5]], [[1ue7]], [[1ue6]] – SSB – ''Mycobacterium tuberculosis'' <br />
-[[1x3e]], [[1x3f]], [[1x3g]] – MsSSB – ''Mycobacterium smegmatis'' <br />
+**[[1x3e]], [[1x3f]], [[1x3g]] – MsSSB – ''Mycobacterium smegmatis'' <br />
-[[1se8]] – DrSSB – ''Deinococcus radiodurans'' <br />
+**[[1se8]] – DrSSB – ''Deinococcus radiodurans'' <br />
-[[4exw]] – SSB DdrB – ''Deinococcus geothermalis'' <br />
+**[[4exw]] – SSB DdrB – ''Deinococcus geothermalis'' <br />
-[[1z9f]] – SSB – ''Thermotoga maritima'' <br />
+**[[1z9f]] – SSB – ''Thermotoga maritima'' <br />
-[[2cwa]] – SSB – ''Thermus thermophilus'' <br />
+**[[2cwa]] – SSB – ''Thermus thermophilus'' <br />
-[[2fxq]], [[2ihe]] – TaSSB – ''Thermus aquaticus'' <br />
+**[[2fxq]], [[2ihe]] – TaSSB – ''Thermus aquaticus'' <br />
-[[2ihf]] – TaSSB (mutant) <br />
+**[[2ihf]] – TaSSB (mutant) <br />
-[[2hql]] – SSB – ''Mycoplasma pneumoniae'' <br />
+**[[2hql]] – SSB – ''Mycoplasma pneumoniae'' <br />
-[[3eiv]] – ScSSB – ''Streptomyces coelicolor''<br />
+**[[3eiv]] – ScSSB – ''Streptomyces coelicolor''<br />
-[[4dam]] – ScSSB (mutant) <br />
+**[[4dam]] – ScSSB (mutant) <br />
-[[3lgj]], [[3pgz]] – SSB – ''Bartonella henselae'' <br />
+**[[3lgj]], [[3pgz]] – SSB – ''Bartonella henselae'' <br />
-[[3afp]], [[3afq]] – SSB – ''Mycobacterium leprae'' <br />
+**[[3afp]], [[3afq]] – SSB – ''Mycobacterium leprae'' <br />
-[[3tqy]] – SSB – ''Coxiella burnetii'' <br />
+**[[3tqy]] – SSB – ''Coxiella burnetii'' <br />
-[[3tek]] – SSB N terminal – ''Thermoproteus tenax''<br />
+**[[3tek]] – SSB N terminal – ''Thermoproteus tenax''<br />
-[[4gs3]] – SSB N terminal – ''Thermoanaerobacter tengcongensis''<br />
+**[[4gs3]] – SSB N terminal – ''Thermoanaerobacter tengcongensis''<br />
-[[3dm3]] – SSB A domain – ''Methancaldococcus jannaschii''<br />
+**[[3dm3]] – SSB A domain – ''Methancaldococcus jannaschii''<br />
-[[1vqe]], [[1yha]], [[1vqb]] – F1SSB – Enterobacteria phage F1<br />
+**[[1vqe]], [[1yha]], [[1vqb]] – F1SSB – Enterobacteria phage F1<br />
-[[2gn5]] – M13SSB – Enterobacteria phage M13<br />
+**[[2gn5]] – M13SSB – Enterobacteria phage M13<br />
-[[2gva]], [[2gvb]] – M13SSB (mutant) - NMR<br />
+**[[2gva]], [[2gvb]] – M13SSB (mutant) - NMR<br />
-[[1vqa]], [[1vqc]], [[1vqd]], [[1vqe]], [[1vqf]], [[1vqg]], [[1vqh]], [[1vqi]], [[1vqj]], [[1ae2]], [[1ae3]], [[1gkh]], [[1SSB]]   – F1SSB (mutant) <br />
+**[[1vqa]], [[1vqc]], [[1vqd]], [[1vqe]], [[1vqf]], [[1vqg]], [[1vqh]], [[1vqi]], [[1vqj]], [[1ae2]], [[1ae3]], [[1gkh]], [[1SSB]] – F1SSB (mutant) <br />
-===SSB complex with ssDNA===
+*Single-stranded DNA-binding protein complex with ssDNA
-[[1eyg]] – EcSSB chymotryptic domain + ssDNA <br />
+**[[1eyg]] – EcSSB chymotryptic domain + ssDNA <br />
-[[1eqq]] – EcSSB + ssDNA <br />
+**[[1eqq]] – EcSSB + ssDNA <br />
-[[2vw9]] – HpSSB + ssDNA <br />
+**[[2vw9]] – HpSSB + ssDNA <br />
-[[3vdy]] – SSB + ssDNA – ''Bacillus subtilis''<br />
+**[[3vdy]] – SSB + ssDNA – ''Bacillus subtilis''<br />
-[[3a5u]] – MsSSB chymotryptic domain + ssDNA <br />
+**[[3a5u]] – MsSSB chymotryptic domain + ssDNA <br />
-[[3udg]] – DrSSB + ssDNA <br />
+**[[3udg]] – DrSSB + ssDNA <br />
-===SSB other complexes===
+*Other single-stranded DNA-binding protein complexes
-[[3ufm]], [[3uf7]] – DrSSB C terminal + uracil-DNA glycosylase <br />
+**[[3ufm]], [[3uf7]] – DrSSB C terminal + uracil-DNA glycosylase <br />
-===Replication protein A===
+*Replication protein A70
-''RPA70''
+**[[1ewi]], [[2b29]] - hRPA70 N terminal - NMR<br />
+**[[4ipc]], [[4ipd]], [[4ipg]] - hRPA70 N terminal (mutant) <br />
+**[[1fgu]] – hRPA70 central domain  <br />
+**[[1ynx]] – yRPA69 DBD-A – yeast – NMR<br />
+**[[1jmc]] – hRPA70 central domain + DNA <br />
+**[[2b3g]] - hRPA70 N terminal + p53 peptide<br />
+**[[4nb3]] - hRPA70 N terminal (mutant) + peptide<br />
+**[[4ijh]], [[4ijl]], [[4iph]], [[4luo]], [[4luv]], [[4luz]], [[4lw1]], [[4lwc]], [[4o0a]] - hRPA70 N terminal (mutant) + inhibitor<br />
-[[1ewi]], [[2b29]] - hRPA70 N terminal - NMR<br />
+*Replication protein A70+A14+A32
-[[4ipc]], [[4ipd]], [[4ipg]] - hRPA70 N terminal (mutant) <br />
-[[1fgu]] – hRPA70 central domain  <br />
-[[1ynx]] – yRPA69 DBD-A – yeast – NMR<br />
-[[1jmc]] – hRPA70 central domain + DNA <br />
-[[2b3g]] - hRPA70 N terminal + p53 peptide<br />
-[[4nb3]] - hRPA70 N terminal (mutant) + peptide<br />
-[[4ijh]], [[4ijl]], [[4iph]], [[4luo]], [[4luv]], [[4luz]], [[4lw1]], [[4lwc]], [[4o0a]] - hRPA70 N terminal (mutant) + inhibitor<br />
-''RPA14 + RPA32 + RPA70''
-[[1l1o]] – hRPA14 + hRPA32 central domain + hRPA70 C terminal <br />
+**[[1l1o]] – hRPA14 + hRPA32 central domain + hRPA70 C terminal <br />
+}}
 [[Category:Topic Page]]

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