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1otz

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Current revision (14:58, 10 December 2014) (edit) (undo)
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[[Image:1otz.gif|left|200px]]
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#REDIRECT [[4v46]] This PDB entry is obsolete and replaced by 4v46
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{{Structure
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|PDB= 1otz |SIZE=350|CAPTION= <scene name='initialview01'>1otz</scene>, resolution 3.3&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of the BAFF-BAFF-R complex (part I)'''
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==Overview==
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B-cell activating factor (BAFF) is a key regulator of B-lymphocyte development. Its biological role is mediated by the specific receptors BCMA, TACI and BAFF-R. We have determined the crystal structure of the extracellular domain of BAFF-R bound to BAFF at a resolution of 3.3 A. The cysteine-rich domain (CRD) of the BAFF-R extracellular domain adopts a beta-hairpin structure and binds to the virus-like BAFF cage in a 1:1 molar ratio. The conserved DxL motif of BAFF-R is located on the tip of the beta-turn and is indispensable in the binding of BAFF. The crystal structure shows that a unique dimeric contact occurs between the BAFF-R monomers in the virus-like cage complex. The extracellular domain of TACI contains two CRDs, both of which contain the DxL motif. Modeling of TACI-BAFF complex suggests that both CDRs simultaneously interact with the BAFF dimer in the virus-like cage.
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==About this Structure==
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1OTZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTZ OCA].
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==Reference==
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Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation., Kim HM, Yu KS, Lee ME, Shin DR, Kim YS, Paik SG, Yoo OJ, Lee H, Lee JO, Nat Struct Biol. 2003 May;10(5):342-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12715002 12715002]
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[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: MG]]
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[[Category: cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:15:37 2008''
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Current revision

  1. REDIRECT 4v46 This PDB entry is obsolete and replaced by 4v46

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