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| - | [[Image:1vsa.gif|left|200px]]
| + | #REDIRECT [[4v4i]] This PDB entry is obsolete and replaced by 4v4i |
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| - | {{Structure
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| - | |PDB= 1vsa |SIZE=350|CAPTION= <scene name='initialview01'>1vsa</scene>, resolution 3.710Å
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| - | |SITE=
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| - | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>
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| - | |ACTIVITY=
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| - | |GENE=
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| - | |DOMAIN=
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| - | |RELATEDENTRY=[[1gix|1GIX]], [[1giy|1GIY]], [[2ow8|2OW8]]
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| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vsa OCA], [http://www.ebi.ac.uk/pdbsum/1vsa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vsa RCSB]</span>
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| - | }}
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| - | '''Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 1VSA, contains the 50S ribosome subunit. 30S ribosome subunit is in the file 2OW8'''
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| - | ==Overview==
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| - | Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
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| - | ==About this Structure==
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| - | 1VSA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry 1VS9. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSA OCA].
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| - | ==Reference==
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| - | Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements., Korostelev A, Trakhanov S, Laurberg M, Noller HF, Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16962654 16962654]
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| - | [[Category: Protein complex]]
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| - | [[Category: Thermus thermophilus]]
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| - | [[Category: Korostelev, A.]]
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| - | [[Category: Laurberg, M.]]
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| - | [[Category: Noller, H F.]]
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| - | [[Category: Trakhanov, S.]]
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| - | [[Category: crystal structure]]
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| - | [[Category: e site]]
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| - | [[Category: functional complex]]
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| - | [[Category: p site]]
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| - | [[Category: peptidyl transferase center]]
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| - | [[Category: ribosome]]
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| - | [[Category: trna]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:27:59 2008''
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