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| - | [[Image:2j00.gif|left|200px]]<br /><applet load="2j00" size="450" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[4v51]] This PDB entry is obsolete and replaced by 4v51 |
| - | caption="2j00, resolution 2.8Å" />
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| - | '''STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH MRNA, TRNA AND PAROMOMYCIN (PART 1 OF 4). THIS FILE CONTAINS THE 30S SUBUNIT, MRNA, A-, P- AND E-SITE TRNAS AND PAROMOMYCIN FOR MOLECULE I.'''<br />
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| - | ==Overview==
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| - | The crystal structure of the bacterial 70S ribosome refined to 2.8, angstrom resolution reveals atomic details of its interactions with, messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a, kink in the mRNA that demarcates the boundary between A and P sites, which, is potentially important to prevent slippage of mRNA. Metal ions also, stabilize the intersubunit interface. The interactions of E-site tRNA with, the 50S subunit have both similarities and differences compared to those, in the archaeal ribosome. The structure also rationalizes much biochemical, and genetic data on translation.
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| - | ==About this Structure==
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| - | 2J00 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with PAR, MG and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J00 OCA].
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| - | ==Reference==
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| - | Structure of the 70S ribosome complexed with mRNA and tRNA., Selmer M, Dunham CM, Murphy FV 4th, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V, Science. 2006 Sep 29;313(5795):1935-42. Epub 2006 Sep 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16959973 16959973]
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| - | [[Category: Escherichia coli]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Thermus thermophilus]]
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| - | [[Category: Dunham, C.M.]]
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| - | [[Category: Kelley, A.C.]]
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| - | [[Category: Murphy, F.V.]]
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| - | [[Category: Petry, S.]]
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| - | [[Category: Ramakrishnan, V.]]
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| - | [[Category: Selmer, M.]]
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| - | [[Category: Weir, J.R.]]
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| - | [[Category: Weixlbaumer, A.]]
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| - | [[Category: MG]]
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| - | [[Category: PAR]]
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| - | [[Category: ZN]]
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| - | [[Category: mrna]]
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| - | [[Category: paromomycin]]
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| - | [[Category: ribosome]]
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| - | [[Category: translation]]
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| - | [[Category: trna]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 12:29:28 2007''
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