2wrn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:15, 10 December 2014) (edit) (undo)
(Redirecting to 4v5g)
 
Line 1: Line 1:
-
==THE CRYSTAL STRUCTURE OF THE 70S RIBOSOME BOUND TO EF-TU AND TRNA (PART 1 OF 4).==
+
#REDIRECT [[4v5g]] This PDB entry is obsolete and replaced by 4v5g
-
<StructureSection load='2wrn' size='340' side='right' caption='[[2wrn]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
+
-
== Structural highlights ==
+
-
<table><tr><td colspan='2'>[[2wrn]] is a 26 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. The January 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''70S Ribosomes'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_1 10.2210/rcsb_pdb/mom_2010_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRN FirstGlance]. <br>
+
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=KIR:KIRROMYCIN'>KIR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+
-
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=YG:WYBUTOSINE'>YG</scene></td></tr>
+
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wro|2wro]], [[2wrq|2wrq]], [[2wrr|2wrr]], [[1ibk|1ibk]], [[1ibl|1ibl]], [[2uuc|2uuc]], [[2wdk|2wdk]], [[2j02|2j02]], [[1j5e|1j5e]], [[2j00|2j00]], [[1hnx|1hnx]], [[2b9o|2b9o]], [[2wh3|2wh3]], [[2uub|2uub]], [[1vov|1vov]], [[1emi|1emi]], [[1pnx|1pnx]], [[2v46|2v46]], [[2vqf|2vqf]], [[2wh1|2wh1]], [[1n32|1n32]], [[2f4v|2f4v]], [[2jl5|2jl5]], [[1twt|1twt]], [[1qzc|1qzc]], [[2uxd|2uxd]], [[1fka|1fka]], [[1fjg|1fjg]], [[1n36|1n36]], [[2uxc|2uxc]], [[1hnw|1hnw]], [[1l1u|1l1u]], [[1hr0|1hr0]], [[2v48|2v48]], [[2b64|2b64]], [[1xmq|1xmq]], [[2b9m|2b9m]], [[1pn8|1pn8]], [[2wdg|2wdg]], [[1xnr|1xnr]], [[1hnz|1hnz]], [[1dv4|1dv4]], [[1rss|1rss]], [[2wdh|2wdh]], [[1jgq|1jgq]], [[1i94|1i94]], [[1i96|1i96]], [[2uu9|2uu9]], [[1pn7|1pn7]], [[1eg0|1eg0]], [[1ibm|1ibm]], [[2uxb|2uxb]], [[2vqe|2vqe]], [[1g1x|1g1x]], [[1ha3|1ha3]], [[2uua|2uua]], [[1i95|1i95]], [[1xnq|1xnq]], [[1qd7|1qd7]], [[1gix|1gix]], [[1jgo|1jgo]], [[1jgp|1jgp]], [[2c78|2c78]], [[1n34|1n34]], [[1n33|1n33]], [[1pns|1pns]], [[2jl7|2jl7]], [[1yl4|1yl4]], [[2wdm|2wdm]], [[1xmo|1xmo]], [[1i97|1i97]], [[2wrj|2wrj]], [[2wri|2wri]], [[2wrk|2wrk]], [[2wrl|2wrl]]</td></tr>
+
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-synthesizing_GTPase Protein-synthesizing GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.3 3.6.5.3] </span></td></tr>
+
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrn RCSB], [http://www.ebi.ac.uk/pdbsum/2wrn PDBsum]</span></td></tr>
+
-
<table>
+
-
== Evolutionary Conservation ==
+
-
[[Image:Consurf_key_small.gif|200px|right]]
+
-
Check<jmol>
+
-
<jmolCheckbox>
+
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wrn_consurf.spt"</scriptWhenChecked>
+
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
-
<text>to colour the structure by Evolutionary Conservation</text>
+
-
</jmolCheckbox>
+
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
-
<div style="clear:both"></div>
+
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
The ribosome selects a correct transfer RNA (tRNA) for each amino acid added to the polypeptide chain, as directed by messenger RNA (mRNA). Aminoacyl-tRNA is delivered to the ribosome by elongation factor Tu (EF-Tu), which hydrolyzes guanosine triphosphate (GTP) and releases tRNA in response to codon recognition. The signaling pathway that leads to GTP hydrolysis upon codon recognition is critical to accurate decoding. Here, we present the crystal structure of the ribosome complexed with EF-Tu and aminoacyl-tRNA, refined to 3.6 angstrom resolution. The structure reveals details of the tRNA distortion that allows aminoacyl-tRNA to interact simultaneously with the decoding center of the 30S subunit and EF-Tu at the factor-binding site. A series of conformational changes in EF-Tu and aminoacyl-tRNA suggest a communication pathway between the decoding center and the guanosine triphosphatase center of EF-Tu.
+
-
 
+
-
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA.,Schmeing TM, Voorhees RM, Kelley AC, Gao YG, Murphy FV 4th, Weir JR, Ramakrishnan V Science. 2009 Oct 15. PMID:19833920<ref>PMID:19833920</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
 
+
-
==See Also==
+
-
*[[Elongation factor|Elongation factor]]
+
-
*[[Ribosomal protein THX|Ribosomal protein THX]]
+
-
*[[Ribosome 3D structures|Ribosome 3D structures]]
+
-
== References ==
+
-
<references/>
+
-
__TOC__
+
-
</StructureSection>
+
-
[[Category: 70S Ribosomes]]
+
-
[[Category: Escherichia coli]]
+
-
[[Category: Protein-synthesizing GTPase]]
+
-
[[Category: RCSB PDB Molecule of the Month]]
+
-
[[Category: Thermus thermophilus]]
+
-
[[Category: Ramakrishnan, V.]]
+
-
[[Category: Schmeing, T M.]]
+
-
[[Category: Voorhees, R M.]]
+
-
[[Category: Decoding]]
+
-
[[Category: Ef-tu]]
+
-
[[Category: Elongation factor]]
+
-
[[Category: Gtpase]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Protein biosynthesis]]
+
-
[[Category: Ribonucleoprotein]]
+
-
[[Category: Ribosomal protein]]
+
-
[[Category: Ribosome]]
+
-
[[Category: Rna-binding]]
+
-
[[Category: Rrna-binding]]
+
-
[[Category: Translation]]
+
-
[[Category: Trna]]
+
-
[[Category: Zinc-finger]]
+

Current revision

  1. REDIRECT 4v5g This PDB entry is obsolete and replaced by 4v5g

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wrn"
Personal tools