Ubiquitin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 35: Line 35:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
=== Ubiquitin ===
+
* Ubiquitin
-
[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br />
+
**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br />
-
[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]] - hUBB<br />
+
**[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]] - hUBB<br />
-
[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]] - hUBB (mutant)<br />
+
**[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]] - hUBB (mutant)<br />
-
[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
+
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
-
[[2m0x]] - hUBB - engineered – NMR<br />
+
**[[2m0x]] - hUBB - engineered – NMR<br />
-
[[1gjz]], [[2l3z]] – hUBB N-terminal – NMR<br />
+
**[[1gjz]], [[2l3z]] – hUBB N-terminal – NMR<br />
-
[[1e0q]] - hUBB N-terminal (mutant) – NMR<br />
+
**[[1e0q]] - hUBB N-terminal (mutant) – NMR<br />
-
[[3q3f]] – hUBB/ribonuclease<br />
+
**[[3q3f]] – hUBB/ribonuclease<br />
-
[[2k39]] – UBB – ''Xenopus laevis'' – NMR<br />
+
**[[2k39]] – UBB – ''Xenopus laevis'' – NMR<br />
-
[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br />
+
**[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br />
-
[[1cmx]] – yUBB (modified)<br />
+
**[[1cmx]] – yUBB (modified)<br />
-
[[2zcc]] – bUBB - bovine<br />
+
**[[2zcc]] – bUBB - bovine<br />
-
=== Ubiquitin+UBB-activating enzymes ===
+
* Ubiquitin+UBB-activating enzymes
-
[[3cmm]] – yUBB+E1 <br />
+
**[[3cmm]] – yUBB+E1 <br />
-
[[3k9p]], [[3a33]] – hUBB+E2<br />
+
**[[3k9p]], [[3a33]] – hUBB+E2<br />
-
[[2gmi]] - hUBB+E2+MMS2<br />
+
**[[2gmi]] - hUBB+E2+MMS2<br />
-
[[2kjh]], [[1zgu]] – hUBB (mutant)+E2<br />
+
**[[2kjh]], [[1zgu]] – hUBB (mutant)+E2<br />
-
[[3jvz]], [[3jw0]] – hUBB+E2+E3<br />
+
**[[3jvz]], [[3jw0]] – hUBB+E2+E3<br />
-
=== Ubiquitin+1 mutant ===
+
* Ubiquitin+1 mutant
-
[[2kx0]] – hUBB+1 – human – NMR<br />
+
**[[2kx0]] – hUBB+1 – human – NMR<br />
-
[[3k9o]] – hUBB+1+E2<br />
+
**[[3k9o]] – hUBB+1+E2<br />
-
=== Ubiquitin dimer===
+
* Ubiquitin dimer
-
[[2xk5]], [[3nob]], [[2xew]], [[3h7p]], [[3h7s]], [[2w9n]], [[2jf5]], [[3ns8]], [[3aul]], [[3axc]] – hDiUBB<br />
+
**[[2xk5]], [[3nob]], [[2xew]], [[3h7p]], [[3h7s]], [[2w9n]], [[2jf5]], [[3ns8]], [[3aul]], [[3axc]] – hDiUBB<br />
-
[[2mbo]], [[2mbq]] – hDiUBB – NMR<br />
+
**[[2mbo]], [[2mbq]] – hDiUBB – NMR<br />
-
[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br />
+
**[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br />
-
[[2bgf]] – hDiUBB – chemical relaxation<br />
+
**[[2bgf]] – hDiUBB – chemical relaxation<br />
-
=== Ubiquitin dimer bound to protein ===
+
* Ubiquitin dimer bound to protein
-
[[3a9j]], [[3a9k]], [[2wwz]], [[2wx0]], [[2wx1]] – hDiUBB+mitogen-activated protein kinase<br />
+
**[[3a9j]], [[3a9k]], [[2wwz]], [[2wx0]], [[2wx1]] – hDiUBB+mitogen-activated protein kinase<br />
-
[[3jsv]], [[2zvn]], [[2zvo]] – hDiUBB+NF-κ-b essential modulator<br />
+
**[[3jsv]], [[2zvn]], [[2zvo]] – hDiUBB+NF-κ-b essential modulator<br />
-
[[2kde]], [[2kdf]] – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR<br />
+
**[[2kde]], [[2kdf]] – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR<br />
-
[[3a1q]] – mDiUBB+UBB interaction motif-containing protein <br />
+
**[[3a1q]] – mDiUBB+UBB interaction motif-containing protein <br />
-
[[3dvg]], [[3dvn]] – hDiUBB+IGG1 fab light&heavy chains<br />
+
**[[3dvg]], [[3dvn]] – hDiUBB+IGG1 fab light&heavy chains<br />
-
[[2znv]] – mDiUBB+hAMSH-like protease<br />[[3ptf]] – hDiUBB + UBB conjugating enzyme E2<br />
+
**[[2znv]] – mDiUBB+hAMSH-like protease<br />[[3ptf]] – hDiUBB + UBB conjugating enzyme E2<br />
-
[[3b08]], [[3b0a]] – hDiUBB + HOIL-1<br />
+
**[[3b08]], [[3b0a]] – hDiUBB + HOIL-1<br />
-
[[3u30]] – hDiUBB + antibody<br />
+
**[[3u30]] – hDiUBB + antibody<br />
-
[[4hxd]] – hDiUBB + RNA polymerase <br />
+
**[[4hxd]] – hDiUBB + RNA polymerase <br />
-
[[2lvp]], [[2lvq]] – hDiUBB + E3 UBB protein ligase - NMR<br />
+
**[[2lvp]], [[2lvq]] – hDiUBB + E3 UBB protein ligase - NMR<br />
-
[[4ksk]], [[4ksl]] – hDiUBB + Fam105B<br />
+
**[[4ksk]], [[4ksl]] – hDiUBB + Fam105B<br />
-
[[4fjv]] – hDiUBB + UBB thiolesterase <br />
+
**[[4fjv]] – hDiUBB + UBB thiolesterase <br />
-
[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
+
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
-
=== Ubiquitin trimer ===
+
* Ubiquitin trimer
-
[[3zlz]] – hTriUBB (mutant) <br />
+
**[[3zlz]] – hTriUBB (mutant) <br />
-
[[4boz]] – hTriUBB + UBB thiolesterase <br />
+
**[[4boz]] – hTriUBB + UBB thiolesterase <br />
-
[[3vuw]], [[3vux]], [[3vuy]] – hTriUBB + TNF α-induced proitein <br />
+
**[[3vuw]], [[3vux]], [[3vuy]] – hTriUBB + TNF α-induced proitein <br />
-
=== Ubiquitin tetramer ===
+
* Ubiquitin tetramer
-
[[3tmp]] – hTetraUBB + deubiquitinase<br />
+
**[[3tmp]] – hTetraUBB + deubiquitinase<br />
-
[[3alb]], [[3hm3]], [[2o6v]], [[1f9j]], [[1tbe]] – tetra-hUBB<br />
+
**[[3alb]], [[3hm3]], [[2o6v]], [[1f9j]], [[1tbe]] – tetra-hUBB<br />
-
[[3zni]] – hTetraUBB + E3 UBB protein ligase + tyrosine protein kinase + UBB conjugating enzyme E2<br />
+
**[[3zni]] – hTetraUBB + E3 UBB protein ligase + tyrosine protein kinase + UBB conjugating enzyme E2<br />
-
=== Ubiquitin bound to protein ===
+
* Ubiquitin monomer bound to protein
-
[[3ofi]] – hUBB+insulin protease
+
**[[3ofi]] – hUBB+insulin protease
-
[[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]], [[3v6c]], [[3v6e]– hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain<br />
+
**[[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]], [[3v6c]], [[3v6e]– hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain<br />
-
[[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]], [[2wdt]], [[4i6l]], [[4i6n]], [[4ig7]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br />
+
**[[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]], [[2wdt]], [[4i6l]], [[4i6n]], [[4ig7]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br />
-
[[2khw]] – hUBB+immunoglobulin G-binding protein G<br />
+
**[[2khw]] – hUBB+immunoglobulin G-binding protein G<br />
-
[[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR<br />
+
**[[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR<br />
-
[[2k6d]] – hUBB+SH3 domain-containing kinase-binding protein – NMR<br />
+
**[[2k6d]] – hUBB+SH3 domain-containing kinase-binding protein – NMR<br />
-
[[2z59]] – hUBB+mProtein Adhesion-regulating molecule 1<br />
+
**[[2z59]] – hUBB+mProtein Adhesion-regulating molecule 1<br />
-
[[2jy6]] – hUBB+hUbiquilin – NMR<br />
+
**[[2jy6]] – hUBB+hUbiquilin – NMR<br />
-
[[3by4]], [[3c0r]] – hUBB+yUBB thioesterase<br />
+
**[[3by4]], [[3c0r]] – hUBB+yUBB thioesterase<br />
-
[[2hth]] – hUBB+vacuolar protein sorting protein<br />
+
**[[2hth]] – hUBB+vacuolar protein sorting protein<br />
-
[[1s1q]] – hUBB+tumor susceptibility gene 101 protein<br />
+
**[[1s1q]] – hUBB+tumor susceptibility gene 101 protein<br />
-
[[1q5w]] – hUBB+NPL4 zinc-fingers<br />
+
**[[1q5w]] – hUBB+NPL4 zinc-fingers<br />
-
[[2k8b]], [[2k8c]] – hUBB+phospholipase A2-activating protein fragment<br />
+
**[[2k8b]], [[2k8c]] – hUBB+phospholipase A2-activating protein fragment<br />
-
[[2ktf]] – hUBB+hDNA polymerase IOTA<br />
+
**[[2ktf]] – hUBB+hDNA polymerase IOTA<br />
-
[[2l0f]] – hUBB (mutant)+hDNA polymerase IOTA<br />
+
**[[2l0f]] – hUBB (mutant)+hDNA polymerase IOTA<br />
-
[[2kwu]], [[2kwv]] - hUBB+mDNA polymerase IOTA – mouse<br />
+
**[[2kwu]], [[2kwv]] - hUBB+mDNA polymerase IOTA – mouse<br />
-
[[2l0t]] – hUBB+signal transducing adapter molecule 2<br />
+
**[[2l0t]] – hUBB+signal transducing adapter molecule 2<br />
-
[[3o65]] – hUBB+ataxin-3-like protein josephin domain<br />
+
**[[3o65]] – hUBB+ataxin-3-like protein josephin domain<br />
-
[[3oj3]] – hUBB+tumor necrosis factor -induced protein 3<br />
+
**[[3oj3]] – hUBB+tumor necrosis factor -induced protein 3<br />
-
[[3phd]] – hPolyUBB+histone deacetylase 6<br />
+
**[[3phd]] – hPolyUBB+histone deacetylase 6<br />
-
[[3znh]] – hPolyUBB-B + UBB thioesterase<br />
+
**[[3znh]] – hPolyUBB-B + UBB thioesterase<br />
-
[[3znz]] – hPolyUBB-C + otulin<br />
+
**[[3znz]] – hPolyUBB-C + otulin<br />
-
[[4jqw]] – hPolyUBB-C + NOD1 CARD<br />
+
**[[4jqw]] – hPolyUBB-C + NOD1 CARD<br />
-
[[4k1r]] – hPolyUBB-C + SST2<br />
+
**[[4k1r]] – hPolyUBB-C + SST2<br />
-
[[3prm]], [[3prp]] – hUBB+protein L<br />
+
**[[3prm]], [[3prp]] – hUBB+protein L<br />
-
[[3pt2]] – hUBB+RNA polymerase OTU domain<br />
+
**[[3pt2]] – hUBB+RNA polymerase OTU domain<br />
-
[[2rr9]] – hUBB + Uimc1<br />
+
**[[2rr9]] – hUBB + Uimc1<br />
-
[[1fxt]], [[3oj4]], [[3ugb]] – hUBB + UBB conjugating enzyme E2<br />
+
**[[1fxt]], [[3oj4]], [[3ugb]] – hUBB + UBB conjugating enzyme E2<br />
-
[[2fuh]] – hUBB + UBB conjugating enzyme E2 - NMR<br />
+
**[[2fuh]] – hUBB + UBB conjugating enzyme E2 - NMR<br />
-
[[4auq]] – hUBB + UBB conjugating enzyme E2 + livin<br />
+
**[[4auq]] – hUBB + UBB conjugating enzyme E2 + livin<br />
-
[[2g45]] – hUBB + isopeptidase T<br />
+
**[[2g45]] – hUBB + isopeptidase T<br />
-
[[2den]] – hUBB + immunoglobulin G binding protein/ubiquitin-like protein 7 - NMR<br />
+
**[[2den]] – hUBB + immunoglobulin G binding protein/ubiquitin-like protein 7 - NMR<br />
-
[[2oob]], [[2qho]] – hUBB + E3 UBB protein ligase<br />
+
**[[2oob]], [[2qho]] – hUBB + E3 UBB protein ligase<br />
-
[[2lvo]] – hUBB + E3 UBB protein ligase - NMR<br />
+
**[[2lvo]] – hUBB + E3 UBB protein ligase - NMR<br />
-
[[2j7q]] – hUBB + MCMV tegument protein<br />
+
**[[2j7q]] – hUBB + MCMV tegument protein<br />
-
[[4dhj]], [[4dhz]] – hUBB (mutant) + UBB thiolesterase + UBB aldehyde <br />
+
**[[4dhj]], [[4dhz]] – hUBB (mutant) + UBB thiolesterase + UBB aldehyde <br />
-
[[3rul]] – hUBB + dalvancin<br />
+
**[[3rul]] – hUBB + dalvancin<br />
-
[[3vfk]] – hUBB + monodechloro-teicoplanin <br />
+
**[[3vfk]] – hUBB + monodechloro-teicoplanin <br />
-
[[4ium]] – hUBB+ papain-like protease<br />
+
**[[4ium]] – hUBB+ papain-like protease<br />
-
[[2lz6]], [[2mcn]] – hUBB + CD2-associated protein<br />
+
**[[2lz6]], [[2mcn]] – hUBB + CD2-associated protein<br />
-
[[2mbh]] – hUBB + Kreuppel-like factor<br />
+
**[[2mbh]] – hUBB + Kreuppel-like factor<br />
-
[[3tbl]] – hUBB + PCNA<br />
+
**[[3tbl]] – hUBB + PCNA<br />
-
[[3vht]] – hUBB + GFP<br />
+
**[[3vht]] – hUBB + GFP<br />
-
[[4jio]] – hUBB + yBRO1<br />
+
**[[4jio]] – hUBB + yBRO1<br />
-
[[4m0w]] – bUBB + replicase polyprotein<br />
+
**[[4m0w]] – bUBB + replicase polyprotein<br />
-
[[1uzx]] – bUBB+VPS23 UEV<br />
+
**[[1uzx]] – bUBB+VPS23 UEV<br />
-
[[2hd5]] - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br />
+
**[[2hd5]] - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br />
-
[[3ldz]] – bUBB+signal transducing adapter molecule<br />
+
**[[3ldz]] – bUBB+signal transducing adapter molecule<br />
-
[[1v80]], [[1v81]] – bUBB/L40 ribosomal protein fusion - NMR<br />
+
**[[1v80]], [[1v81]] – bUBB/L40 ribosomal protein fusion - NMR<br />
-
[[2dx5]], [[1p3q]] - bUBB+vacuolar protein sorting protein<br />
+
**[[2dx5]], [[1p3q]] - bUBB+vacuolar protein sorting protein<br />
-
[[2c7m]], [[2c7n]], [[2fid]], [[2fif]] – bUBB+RAB guanine nucleotide exchange factor<br />
+
**[[2c7m]], [[2c7n]], [[2fid]], [[2fif]] – bUBB+RAB guanine nucleotide exchange factor<br />
-
[[2d3g]] – bUBB+HRS-UIM<br />
+
**[[2d3g]] – bUBB+HRS-UIM<br />
-
[[1wrd]] – bUBB+TOM1 GAT domain<br />
+
**[1wrd]] – bUBB+TOM1 GAT domain<br />
-
[[1wr6]], [[1yd8]] - bUBB+GGA3 GAT domain<br />
+
**[[1wr6]], [[1yd8]] - bUBB+GGA3 GAT domain<br />
-
[[1uzx]] – bUBB+VPS23 UEV<br />
+
**[[1uzx]] – bUBB+VPS23 UEV<br />
-
[[2kdi]] – yUBB/UIM fusion <br />
+
**[[2kdi]] – yUBB/UIM fusion <br />
-
[[2jt4]] – yUBB fragment+cytoskeleton assembly control protein<br />
+
**[[2jt4]] – yUBB fragment+cytoskeleton assembly control protein<br />
-
[[1q0w]] - yUBB+vacuolar protein sorting protein<br />
+
**[[1q0w]] - yUBB+vacuolar protein sorting protein<br />
-
[[2g3q]] – yUBB+EDE1 UBA<br />
+
**[[2g3q]] – yUBB+EDE1 UBA<br />
-
[[1wr1]] – yUBB+DSK2P UBA<br />
+
**[[1wr1]] – yUBB+DSK2P UBA<br />
-
[[1otr]] – yUBB+CUE2<br />
+
**[[1otr]] – yUBB+CUE2<br />
-
[[2l00]] – yUBB + Zfand5
+
**[[2l00]] – yUBB + Zfand5
-
=== Ubiquitin + ions ===
+
* Ubiquitin + ions
-
 
+
-
[[3h1u]] – bUBB+Cd<br />
+
-
[[3ehv]], [[3eec]], [[3efu]] – hUBB+ions<br />
+
-
[[3n30]], [[4k7s]], [[4k7u]], [[4k7w]] – hUBB+Zn<br />
+
-
[[3n32]] – hUBB+Pt<br />
+
 +
**[[3h1u]] – bUBB+Cd<br />
 +
**[[3ehv]], [[3eec]], [[3efu]] – hUBB+ions<br />
 +
**[[3n30]], [[4k7s]], [[4k7u]], [[4k7w]] – hUBB+Zn<br />
 +
**[[3n32]] – hUBB+Pt<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:31, 16 December 2014

Image:1d3z.png
NMR Structure of Ubiquitin, 1d3z

Template:STRUCTURE 3k9p












Ubiquitin (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. At least 4 UBB molecules are needed to tag a protein for the proteasome. For details see

Additional Resources

See: Ubiquitin Structure & Function for additional information.

3D Structures of Ubiquitin

Updated on 16-December-2014

Retrieved from "http://52.214.119.220/wiki/index.php/Ubiquitin"
Personal tools