Ubiquitin protein ligase

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*Ubiquitin protein ligase AMFR
+
*'''Ubiquitin protein ligase AMFR'''
**[[4g3o]] – hUPL CUE domain<br />
**[[4g3o]] – hUPL CUE domain<br />
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**[[4lad]] – hUPL RING domain (mutant) + E2 G2 <br />
**[[4lad]] – hUPL RING domain (mutant) + E2 G2 <br />
-
*Ubiquitin protein ligase Arkadia
+
*'''Ubiquitin protein ligase Arkadia'''
**[[2kiz]] – hUPL RING-H2 finger domain - NMR<br />
**[[2kiz]] – hUPL RING-H2 finger domain - NMR<br />
-
*Ubiquitin protein ligase CHFR
+
*'''Ubiquitin protein ligase CHFR'''
**[[2xoc]], [[2xoy]], [[2xoz]] – hUPL C terminal + nucleotide<br />
**[[2xoc]], [[2xoy]], [[2xoz]] – hUPL C terminal + nucleotide<br />
**[[2xp0]] – hUPL C terminal <br />
**[[2xp0]] – hUPL C terminal <br />
-
*Ubiquitin protein ligase Cbl
+
*'''Ubiquitin protein ligase Cbl'''
**[[2y1m]] – hUPL - human<br />
**[[2y1m]] – hUPL - human<br />
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**[[4a49]] – hUPL residues 354-435 + ubiquitin conjugating enzyme E2 <br />
**[[4a49]] – hUPL residues 354-435 + ubiquitin conjugating enzyme E2 <br />
-
*Ubiquitin protein ligase CNOT4
+
*'''Ubiquitin protein ligase CNOT4'''
**[[2cpi]] – mUPL RNA recognition motif - NMR <br />
**[[2cpi]] – mUPL RNA recognition motif - NMR <br />
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**[[4a49]] – hUPL residues 354-435 + ubiquitin conjugating enzyme E2 <br />
**[[4a49]] – hUPL residues 354-435 + ubiquitin conjugating enzyme E2 <br />
-
*Ubiquitin protein ligase EDD1
+
*'''Ubiquitin protein ligase EDD1'''
**[[2qho]] – hUPL UBA domain + ubiquitin <br />
**[[2qho]] – hUPL UBA domain + ubiquitin <br />
-
*Ubiquitin protein ligase FANCL
+
*'''Ubiquitin protein ligase FANCL'''
**[[3zqs]] – hUPL residues 109-294<br />
**[[3zqs]] – hUPL residues 109-294<br />
**[[4ccg]] – hUPL RING domain + E2 T<br />
**[[4ccg]] – hUPL RING domain + E2 T<br />
-
*Ubiquitin protein ligase HAKAI
+
*'''Ubiquitin protein ligase HAKAI'''
**[[3vk6]] – mUPL phosphotyrosine-binding domain<br />
**[[3vk6]] – mUPL phosphotyrosine-binding domain<br />
-
*Ubiquitin protein ligase HECTD1
+
*'''Ubiquitin protein ligase HECTD1'''
**[[3dkm]] – hUPL CPH domain <br />
**[[3dkm]] – hUPL CPH domain <br />
**[[2lc3]] – hUPL helical bundle domain - NMR<br />
**[[2lc3]] – hUPL helical bundle domain - NMR<br />
-
*Ubiquitin protein ligase HECW
+
*'''Ubiquitin protein ligase HECW'''
**[[3l4h]] – hUPL WW2 and helical box domains <br />
**[[3l4h]] – hUPL WW2 and helical box domains <br />
**[[2lfe]] – hUPL N terminal - NMR<br />
**[[2lfe]] – hUPL N terminal - NMR<br />
-
*Ubiquitin protein ligase HERC
+
*'''Ubiquitin protein ligase HERC'''
**[[4o2w]] – hUPL 1 3rd RCC1-like domain <br />
**[[4o2w]] – hUPL 1 3rd RCC1-like domain <br />
**[[4l1m]] – hUPL 2 1st RCC1-like domain <br />
**[[4l1m]] – hUPL 2 1st RCC1-like domain <br />
-
*Ubiquitin protein ligase HHARI
+
*'''Ubiquitin protein ligase HHARI'''
**[[4kbl]], [[4kc9]] – hUPL<br />
**[[4kbl]], [[4kc9]] – hUPL<br />
**[[2m9y]] – hUPL catalytic domain - NMR<br />
**[[2m9y]] – hUPL catalytic domain - NMR<br />
-
*Ubiquitin protein ligase HUWE1
+
*'''Ubiquitin protein ligase HUWE1'''
**[[3g1n]] – hUPL catalytic domain <br />
**[[3g1n]] – hUPL catalytic domain <br />
**[[3h1d]] – hUPL HECT domain (mutant)<br />
**[[3h1d]] – hUPL HECT domain (mutant)<br />
-
*Ubiquitin protein ligase ITCHY
+
*'''Ubiquitin protein ligase ITCHY'''
**[[2jo9]] – mUPL WW3 domain + Epstein-Barr virus peptide - NMR <br />
**[[2jo9]] – mUPL WW3 domain + Epstein-Barr virus peptide - NMR <br />
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*'''Ubiquitin protein ligase TRIM'''
*'''Ubiquitin protein ligase TRIM'''
-
[[3zo0]] – mUPL 21 residues 291-470 + IG γ-2A<br />
+
**[[3zo0]] – mUPL 21 residues 291-470 + IG γ-2A<br />
-
[[4b8e]] – mUPL 25 PRY-SPRY domain <br />
+
**[[4b8e]] – mUPL 25 PRY-SPRY domain <br />
-
[[3u5m]] – hUPL 33 PHD+Bromo domains <br />
+
**[[3u5m]] – hUPL 33 PHD+Bromo domains <br />
-
[[3u5n]], [[3u5o]], [[3u5p]] – hUPL 33 PHD+Bromo domain + H3-histone peptide <br />
+
**[[3u5n]], [[3u5o]], [[3u5p]] – hUPL 33 PHD+Bromo domain + H3-histone peptide <br />
-
[[3ddt]] – hUPL 37 B2-box <br />
+
**[[3ddt]] – hUPL 37 B2-box <br />
-
[[4m3l]] – hUPL 63 coiled-coil domain <br />
+
**[[4m3l]] – hUPL 63 coiled-coil domain <br />
-
[[4nqj]] – hUPL 69 coiled-coil domain <br />
+
**[[4nqj]] – hUPL 69 coiled-coil domain <br />
-
===UPL UBR===
+
*'''Ubiquitin protein ligase UBR'''
-
[[3ny1]], [[3ny2]] – hUPL UBR-box <br />
+
**[[3ny1]], [[3ny2]] – hUPL UBR-box <br />
-
[[3pt3]] – hUPL C terminal <br />
+
**[[3pt3]] – hUPL C terminal <br />
-
[[3ny3]] – hUPL UBR-box + N-degron<br />
+
**[[3ny3]] – hUPL UBR-box + N-degron<br />
-
[[3nih]], [[3nii]], [[3nij]], [[3nik]], [[3nil]], [[3nim]], [[3nin]] – yUPL UBR-box + peptide - yeast<br />
+
**[[3nih]], [[3nii]], [[3nij]], [[3nik]], [[3nil]], [[3nim]], [[3nin]] – yUPL UBR-box + peptide - yeast<br />
-
[[3nis]], [[3nit]] – yUPL UBR-box <br />
+
**[[3nis]], [[3nit]] – yUPL UBR-box <br />
-
[[3ntw]] – rUPL MLLE domain + peptide <br />
+
**[[3ntw]] – rUPL MLLE domain + peptide <br />
-
===UPL UHRF (Np95)===
+
*'''Ubiquitin protein ligase UHRF (Np95)'''
-
[[3sox]], [[3zvz]] – hUPL 1 PHD finger <br />
+
**[[3sox]], [[3zvz]] – hUPL 1 PHD finger <br />
-
[[2lgl]] – hUPL 1 PHD finger - NMR <br />
+
**[[2lgl]] – hUPL 1 PHD finger - NMR <br />
-
[[2e6s]] – hUPL 2 PHD finger - NMR <br />
+
**[[2e6s]] – hUPL 2 PHD finger - NMR <br />
-
[[3zvy]] – hUPL 1 PHD finger + histone H3 peptide<br />
+
**[[3zvy]] – hUPL 1 PHD finger + histone H3 peptide<br />
-
[[3bi7]], [[2pb7]], [[2zkg]], [[3dwh]] – hUPL 1 SRA domain <br />
+
**[[3bi7]], [[2pb7]], [[2zkg]], [[3dwh]] – hUPL 1 SRA domain <br />
-
[[3oln]] – hUPL 2 SRA domain <br />
+
**[[3oln]] – hUPL 2 SRA domain <br />
-
[[3db4]] – hUPL 1 TUDOR domain <br />
+
**[[3db4]] – hUPL 1 TUDOR domain <br />
-
[[3fl2]] – hUPL 1 RING domain <br />
+
**[[3fl2]] – hUPL 1 RING domain <br />
-
''UPL UHRF complex''
+
*Ubiquitin protein ligase UHRF complex
-
[[3clz]], [[2zkd]], [[2zke]], [[2zkf]] – hUPL 1 SRA domain + DNA<br />
+
**[[3clz]], [[2zkd]], [[2zke]], [[2zkf]] – hUPL 1 SRA domain + DNA<br />
-
[[4pw5]], [[4pw6]], [[4pw7]] – hUPL 2 SRA domain + DNA<br />
+
**[[4pw5]], [[4pw6]], [[4pw7]] – hUPL 2 SRA domain + DNA<br />
-
[[2zo0]], [[2zo1]], [[2zo2]], [[3f8i]], [[3f8j]], [[3fde]] – mUPL 1 SRA domain + DNA<br />
+
**[[2zo0]], [[2zo1]], [[2zo2]], [[3f8i]], [[3f8j]], [[3fde]] – mUPL 1 SRA domain + DNA<br />
-
[[3sou]], [[3sow]], [[3shb]], [[2lgg]], [[3t6r]], [[3ask]], [[3asl]], [[4gy5]] – hUPL 1 PHD finger + histone H3 peptide<br />
+
**[[3sou]], [[3sow]], [[3shb]], [[2lgg]], [[3t6r]], [[3ask]], [[3asl]], [[4gy5]] – hUPL 1 PHD finger + histone H3 peptide<br />
-
[[2lgk]] – hUPL 1 PHD finger + histone H3 peptide - NMR<br />
+
**[[2lgk]] – hUPL 1 PHD finger + histone H3 peptide - NMR<br />
-
[[3db3]] – hUPL 1 TUDOR domain + histone H3 peptide<br />
+
**[[3db3]] – hUPL 1 TUDOR domain + histone H3 peptide<br />
-
[[2l3r]] – hUPL 1 TUDOR domain + histone H3 peptide - NMR<br />
+
**[[2l3r]] – hUPL 1 TUDOR domain + histone H3 peptide - NMR<br />
-
===UPL WWP1===
+
*'''Ubiquitin protein ligase WWP1'''
-
[[2jqz]] – hUPL WW4 domain - NMR <br />
+
**[[2jqz]] – hUPL WW4 domain - NMR <br />
-
===UPL XIAP===
+
*'''Ubiquitin protein ligase XIAP'''
-
''XIAP BIR-1 domain''
+
*Ubiquitin protein ligase XIAP BIR-1 domain
-
[[2poi]], [[2qra]] – hXIAP – human <BR />
+
**[[2poi]], [[2qra]] – hXIAP – human <BR />
-
[[2pop]] – hXIAP + TAB1 <BR />
+
**[[2pop]] – hXIAP + TAB1 <BR />
-
''XIAP BIR-2 domain''
+
*Ubiquitin protein ligase XIAP BIR-2 domain
-
[[1c9q]] – hXIAP (mutant) – NMR <BR />
+
**[[1c9q]] – hXIAP (mutant) – NMR <BR />
-
[[4j3y]] – hXIAP (mutant) <BR />
+
**[[4j3y]] – hXIAP (mutant) <BR />
-
[[4j44]], [[4j45]], [[4j46]], [[4j47]], [[4j48]] - hXIAP (mutant) + peptide<BR />
+
**[[4j44]], [[4j45]], [[4j46]], [[4j47]], [[4j48]] - hXIAP (mutant) + peptide<BR />
-
[[1i3o]] – hXIAP (mutant) + caspase-3 <BR />
+
**[[1i3o]] – hXIAP (mutant) + caspase-3 <BR />
-
[[1i4o]], [[1kmc]], [[1i51]] – hXIAP + caspase-7 <BR />
+
**[[1i4o]], [[1kmc]], [[1i51]] – hXIAP + caspase-7 <BR />
-
[[4kmp]] - hXIAP + inhibitor<BR />
+
**[[4kmp]] - hXIAP + inhibitor<BR />
-
[[4kju]], [[4kjv]] - hXIAP (mutant) + inhibitor<BR />
+
**[[4kju]], [[4kjv]] - hXIAP (mutant) + inhibitor<BR />
-
[[3uw5]] – hXIAP residues 63-179 (mutant) + GDC0152 + inhibitor<br /> <BR />
+
**[[3uw5]] – hXIAP residues 63-179 (mutant) + GDC0152 + inhibitor<br /> <BR />
-
''XIAP BIR-3 domain''
+
*Ubiquitin protein ligase XIAP BIR-3 domain
-
[[1f9x]] – hXIAP – NMR <BR />
+
**[[1f9x]] – hXIAP – NMR <BR />
-
[[1g3f]] – hXIAP + Smac peptide – NMR <BR />
+
**[[1g3f]] – hXIAP + Smac peptide – NMR <BR />
-
[[2opz]] – hXIAP + Smac peptide <BR />
+
**[[2opz]] – hXIAP + Smac peptide <BR />
-
[[2opy]], [[2vsl]], [[3clx]], [[3cm2]], [[3cm7]], [[2jk7]], [[3eyl]], [[3g76]], [[4ec4]] – hXIAP + Smac mimic <BR />
+
**[[2opy]], [[2vsl]], [[3clx]], [[3cm2]], [[3cm7]], [[2jk7]], [[3eyl]], [[3g76]], [[4ec4]] – hXIAP + Smac mimic <BR />
-
[[1g73]] – hXIAP + Smac <BR />
+
**[[1g73]] – hXIAP + Smac <BR />
-
[[1nw9]] – hXIAP + caspase-9 <BR />
+
**[[1nw9]] – hXIAP + caspase-9 <BR />
-
[[1tfq]], [[1tft]] – hXIAP + inhibitor - NMR <BR />
+
**[[1tfq]], [[1tft]] – hXIAP + inhibitor - NMR <BR />
-
[[3hl5]], [[4hy0]] – hXIAP + inhibitor <BR />
+
**[[3hl5]], [[4hy0]] – hXIAP + inhibitor <BR />
-
[[3uw4]] – hXIAP (mutant) + peptide + inhibitor <BR />
+
**[[3uw4]] – hXIAP (mutant) + peptide + inhibitor <BR />
-
''XIAP UBA domain''
+
*Ubiquitin protein ligase XIAP UBA domain
-
[[2kna]] – hXIAP – NMR <BR />
+
**[[2kna]] – hXIAP – NMR <BR />
-
''XIAP RING domain''
+
*Ubiquitin protein ligase XIAP RING domain
-
[[4ic2]] – hXIAP <BR />
+
**[[4ic2]] – hXIAP <BR />
-
[[2ecg]] – hXIAP – NMR <BR />
+
**[[2ecg]] – hXIAP – NMR <BR />
-
[[4ic3]] – hXIAP (mutant) <BR />
+
**[[4ic3]] – hXIAP (mutant) <BR />
-
 
+
-
 
+
-
===UPL ZNRF3===
+
-
 
+
-
[[4c84]], [[4c85]], [[4c86]], [[4c8a]], [[4c8c]], [[4c8f]] – zUPL ectodomain – zebra fish <br />
+
-
[[4c8p]] – zUPL ectodomain (mutant) <br />
+
-
[[4c8t]], [[4c8u]] – fUPL ectodomain – frog <br />
+
-
[[4cdj]] – mUPL ectodomain <br />
+
-
[[4c99]], [[4c9a]], [[4c9e]], [[4c9r]], [[4c9u]], [[4cdk]] – mUPL ectodomain + R-spondin <br />
+
-
 
+
-
===UPL ZFP91===
+
-
 
+
-
[[2m9a]] – hUPL residues 370-456 - NMR<br />
+
-
 
+
-
 
+
-
+
 +
*'''Ubiquitin protein ligase ZNRF3'''
 +
**[[4c84]], [[4c85]], [[4c86]], [[4c8a]], [[4c8c]], [[4c8f]] – zUPL ectodomain – zebra fish <br />
 +
**[[4c8p]] – zUPL ectodomain (mutant) <br />
 +
**[[4c8t]], [[4c8u]] – fUPL ectodomain – frog <br />
 +
**[[4cdj]] – mUPL ectodomain <br />
 +
**[[4c99]], [[4c9a]], [[4c9e]], [[4c9r]], [[4c9u]], [[4cdk]] – mUPL ectodomain + R-spondin <br />
 +
*'''Ubiquitin protein ligase ZFP91'''
 +
**[[2m9a]] – hUPL residues 370-456 - NMR<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:45, 17 December 2014

Template:STRUCTURE 1c4z

Ubiquitin-protein ligase (UPL) (E3) in combination with ubiquitin-conjugating enzyme (E2) causes the attachment of ubiquitin to lysine to a target protein. UPL XIAP or X-linked Inhibitor of Apoptosis Protein stops apoptosis induced by viral infection or by overproduction of caspases. UPL XIAP binds caspase-3, -7 and -9. UPL can contain several distinct domains like:

  • WW domains which contain 2 tryptophans which bind proline-rich peptide;
  • UBA – Ubiquitin-Associated Domain;
  • TKB – Tyrosine Kinase Binding domain;
  • C2 – an 8 β strand domain which coordinates targeting proteins toward cell membrane;
  • HECT – Homologous to the E6-AP C-terminus;
  • RING – Really Intersting New Gene involved in binding to E2;
  • FHA – Forkhead Associated domain recognizing phosphothreonine;
  • IBR – involved in binding to E2;
  • PHD finger – Plant Homeo Domain is 50-80 amino acid long which contains a CHC motif;
  • SRA – SET and RING-Associated domain;
  • TUDOR – a ca. 50 amino acids long and recognizes dimethylated arginine;
  • CPH – protein-protein interaction domain;
  • UBR – a ca. 70 amino acid long zinc finger-like domain;
  • CUE – a ubiquitin-binding domain.

UPL XIAP consists of 3 BIR (baculoviral IAP repeat) domains, followed by UBA (ubiquitin-binding) domain and RING (C-terminal RING finger) domain. BIR2 inhibits caspase-3 and -7. BIR3 inhibits caspase-9. Overexpression of UPL XIAP functions as tumor marker. UPL XIAP is inhibited by Smac – a death signaling protein. For some details see

3D Structures of ubiquitin protein ligase

Updated on 17-December-2014

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