Uridylate kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1ybd]] – UK – ''Neisseria meningitides''<br />
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*Uridylate kinase
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[[1z9d]] – UK – ''Streptococcus pyogenes''<br />
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[[2a1f]] - UK - ''Haemophilus influenza''<br />
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[[2brx]] – PfUK – ''Pyrococcus furiosus''<br />
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[[2ij9]] – UK (mutant) – ''Archaeoglobus fulgidus''<br />
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[[2va1]] - UK – ''Ureaplasma parvum''<br />
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[[3ek6]] – XcUK – ''Xanthomonas campestris''
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===Uridylate kinase complex with nucleotides===
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**[[1ybd]] – UK – ''Neisseria meningitides''<br />
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**[[1z9d]] – UK – ''Streptococcus pyogenes''<br />
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**[[2a1f]] - UK - ''Haemophilus influenza''<br />
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**[[2brx]] – PfUK – ''Pyrococcus furiosus''<br />
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**[[2ij9]] – UK (mutant) – ''Archaeoglobus fulgidus''<br />
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**[[2va1]] - UK – ''Ureaplasma parvum''<br />
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**[[3ek6]] – XcUK – ''Xanthomonas campestris''
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[[1ukz]] – yUK + AMP + ADP<br />
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*Uridylate kinase complex with nucleotides
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[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br />
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[[2bnd]] - EcUK (mutant) + UDP<br />
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[[2bnf]] - EcUK (mutant) + UTP<br />
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[[2v4y]] - EcUK (mutant) + GTP<br />
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[[2bmu]] - PfUK + UMP + AMPPNP<BR />
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[[2bri]] - PfUK + AMPPNP<BR />
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[[2ji5]] - PfUK (mutant) + UTP<br />
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[[2j4j]] - SsUK + UMP + AMPPCP – Sulfolobus solfataricus<br />
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[[2j4k]] - SsUK + UMP<br />
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[[2j4l]] - SsUK + UTP<br />
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[[2jjx]] - UK + ATP + Mg – ''Bacillus anthracis''<br />
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[[1uky]] – yUK + ADP – yeast<br />
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[[3ek5]] - XcUK + GTP <br />
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[[3nwy]] – UK + UTP + GTP – ''Mycobacterium tuberculosis''<br />
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[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br />
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**[[1ukz]] – yUK + AMP + ADP<br />
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**[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br />
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**[[2bnd]] - EcUK (mutant) + UDP<br />
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**[[2bnf]] - EcUK (mutant) + UTP<br />
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**[[2v4y]] - EcUK (mutant) + GTP<br />
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**[[2bmu]] - PfUK + UMP + AMPPNP<BR />
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**[[2bri]] - PfUK + AMPPNP<BR />
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**[[2ji5]] - PfUK (mutant) + UTP<br />
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**[[2j4j]] - SsUK + UMP + AMPPCP – Sulfolobus solfataricus<br />
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**[[2j4k]] - SsUK + UMP<br />
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**[[2j4l]] - SsUK + UTP<br />
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**[[2jjx]] - UK + ATP + Mg – ''Bacillus anthracis''<br />
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**[[1uky]] – yUK + ADP – yeast<br />
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**[[3ek5]] - XcUK + GTP <br />
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**[[3nwy]] – UK + UTP + GTP – ''Mycobacterium tuberculosis''<br />
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**[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:40, 17 December 2014

Template:STRUCTURE 2j4k

Uridylate kinase (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source. UDP is the starting point of synthesis of all other pyrimidine nucleotides. The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP. The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP. The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain.

3D structures of uridylate kinase

Updated on 17-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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