3k1v
From Proteopedia
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| - | + | ==Cocrystal structure of a mutant class-I preQ1 riboswitch== | |
| - | + | <StructureSection load='3k1v' size='340' side='right' caption='[[3k1v]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3k1v]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3fu4 3fu4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K1V FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k1v RCSB], [http://www.ebi.ac.uk/pdbsum/3k1v PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Riboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis that is selective for the essential nucleobase preQ(1) (7-aminomethyl-7-deazaguanine). The structures reveal a previously unrecognized pseudoknot fold and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional antiterminator. | ||
| - | + | Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.,Klein DJ, Edwards TE, Ferre-D'Amare AR Nat Struct Mol Biol. 2009 Mar;16(3):343-4. Epub 2009 Feb 22. PMID:19234468<ref>PMID:19234468</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Riboswitch|Riboswitch]] | *[[Riboswitch|Riboswitch]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: Amare, A R.Ferre-D | + | </StructureSection> |
| - | [[Category: Edwards, T E | + | [[Category: Amare, A R.Ferre-D]] |
| - | [[Category: Klein, D J | + | [[Category: Edwards, T E]] |
| + | [[Category: Klein, D J]] | ||
[[Category: Aptamer]] | [[Category: Aptamer]] | ||
[[Category: Preq1]] | [[Category: Preq1]] | ||
Revision as of 06:35, 18 December 2014
Cocrystal structure of a mutant class-I preQ1 riboswitch
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Categories: Amare, A R.Ferre-D | Edwards, T E | Klein, D J | Aptamer | Preq1 | Queuosine | Riboswitch | Rna
