1q1p

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[[Image:1q1p.gif|left|200px]]<br /><applet load="1q1p" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1q1p.gif|left|200px]]
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caption="1q1p, resolution 3.20&Aring;" />
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'''E-Cadherin activation'''<br />
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{{Structure
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|PDB= 1q1p |SIZE=350|CAPTION= <scene name='initialview01'>1q1p</scene>, resolution 3.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE= CDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''E-Cadherin activation'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Q1P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1P OCA].
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1Q1P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1P OCA].
==Reference==
==Reference==
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Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography., Haussinger D, Ahrens T, Aberle T, Engel J, Stetefeld J, Grzesiek S, EMBO J. 2004 Apr 21;23(8):1699-708. Epub 2004 Apr 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15071499 15071499]
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Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography., Haussinger D, Ahrens T, Aberle T, Engel J, Stetefeld J, Grzesiek S, EMBO J. 2004 Apr 21;23(8):1699-708. Epub 2004 Apr 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15071499 15071499]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: cell-adhesion]]
[[Category: cell-adhesion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:34:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:31:50 2008''

Revision as of 11:31, 20 March 2008

Image:1q1p.gif


PDB ID 1q1p

Drag the structure with the mouse to rotate
, resolution 3.20Å
Ligands:
Gene: CDH1 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



E-Cadherin activation


Overview

Cellular adhesion by classical cadherins depends critically on the exact proteolytic removal of their N-terminal prosequences. In this combined solution NMR and X-ray crystallographic study, the consequences of propeptide cleavage of an epithelial cadherin construct (domains 1 and 2) were followed at atomic level. At low protein concentration, the N-terminal processing induces docking of the tryptophan-2 side-chain into a binding pocket on the same molecule. At high concentration, cleavage induces dimerization (KD=0.72 mM, k(off)=0.7 s(-1)) and concomitant intermolecular exchange of the betaA-strands and the tryptophan-2 side-chains. Thus, the cleavage represents the switch from a nonadhesive to the functional form of cadherin.

About this Structure

1Q1P is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography., Haussinger D, Ahrens T, Aberle T, Engel J, Stetefeld J, Grzesiek S, EMBO J. 2004 Apr 21;23(8):1699-708. Epub 2004 Apr 8. PMID:15071499

Page seeded by OCA on Thu Mar 20 13:31:50 2008

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