3a1f
From Proteopedia
(Difference between revisions)
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| - | + | ==The crystal structure of NADPH binding domain of gp91(phox)== | |
| - | + | <StructureSection load='3a1f' size='340' side='right' caption='[[3a1f]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[3a1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A1F FirstGlance]. <br> |
| - | [[http://www.uniprot.org/uniprot/CY24B_HUMAN CY24B_HUMAN]] Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD) [MIM:[http://omim.org/entry/306400 306400]]. A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:12139950</ref><ref>PMID:2556453</ref><ref>PMID:1710153</ref><ref>PMID:8101486</ref><ref>PMID:7927345</ref><ref>PMID:8182143</ref><ref>PMID:8916969</ref><ref>PMID:9111587</ref><ref>PMID:9585602</ref><ref>PMID:9856476</ref><ref>PMID:9794433</ref><ref>PMID:9667376</ref><ref>PMID:10089913</ref><ref>PMID:9888386</ref><ref>PMID:10914676</ref><ref>PMID:11462241</ref><ref>PMID:11997083</ref><ref>PMID:15338276</ref><ref>PMID:18773283</ref><ref>PMID:22125116</ref> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a1f RCSB], [http://www.ebi.ac.uk/pdbsum/3a1f PDBsum]</span></td></tr> | |
| - | ==Function== | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CY24B_HUMAN CY24B_HUMAN]] Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD) [MIM:[http://omim.org/entry/306400 306400]]. A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:12139950</ref> <ref>PMID:2556453</ref> <ref>PMID:1710153</ref> <ref>PMID:8101486</ref> <ref>PMID:7927345</ref> <ref>PMID:8182143</ref> <ref>PMID:8916969</ref> <ref>PMID:9111587</ref> <ref>PMID:9585602</ref> <ref>PMID:9856476</ref> <ref>PMID:9794433</ref> <ref>PMID:9667376</ref> <ref>PMID:10089913</ref> <ref>PMID:9888386</ref> <ref>PMID:10914676</ref> <ref>PMID:11462241</ref> <ref>PMID:11997083</ref> <ref>PMID:15338276</ref> <ref>PMID:18773283</ref> <ref>PMID:22125116</ref> Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2) [MIM:[http://omim.org/entry/300645 300645]]. A rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections.<ref>PMID:21278736</ref> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/CY24B_HUMAN CY24B_HUMAN]] Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. | [[http://www.uniprot.org/uniprot/CY24B_HUMAN CY24B_HUMAN]] Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. | ||
| - | + | == Evolutionary Conservation == | |
| - | == | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | == | + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/3a1f_consurf.spt"</scriptWhenChecked> |
| - | <references | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Honbou, K | + | [[Category: Honbou, K]] |
[[Category: Nadph binding domain]] | [[Category: Nadph binding domain]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 14:13, 18 December 2014
The crystal structure of NADPH binding domain of gp91(phox)
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