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3mnv

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{{STRUCTURE_3mnv| PDB=3mnv | SCENE= }}
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==Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment==
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===Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment===
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<StructureSection load='3mnv' size='340' side='right' caption='[[3mnv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21076400}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mnv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MNV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mnw|3mnw]], [[3mnz|3mnz]], [[3mo1|3mo1]], [[3moa|3moa]], [[3mob|3mob]], [[3mod|3mod]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mnv RCSB], [http://www.ebi.ac.uk/pdbsum/3mnv PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.
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==About this Structure==
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Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.,Nicely NI, Dennison SM, Spicer L, Scearce RM, Kelsoe G, Ueda Y, Chen H, Liao HX, Alam SM, Haynes BF Nat Struct Mol Biol. 2010 Dec;17(12):1492-4. Epub 2010 Nov 14. PMID:21076400<ref>PMID:21076400</ref>
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[[3mnv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNV OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:021076400</ref><references group="xtra"/><references/>
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</div>
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==See Also==
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alam, S M.]]
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[[Category: Alam, S M]]
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[[Category: Dennison, S M.]]
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[[Category: Dennison, S M]]
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[[Category: Haynes, B F.]]
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[[Category: Haynes, B F]]
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[[Category: Kelsoe, G.]]
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[[Category: Kelsoe, G]]
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[[Category: Liao, H X.]]
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[[Category: Liao, H X]]
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[[Category: Nicely, N I.]]
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[[Category: Nicely, N I]]
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[[Category: 13h11]]
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[[Category: 2f5]]
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[[Category: 4e10]]
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[[Category: Fab antibody]]
[[Category: Fab antibody]]
[[Category: Gp41]]
[[Category: Gp41]]

Revision as of 14:51, 18 December 2014

Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment

3mnv, resolution 2.40Å

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