3n6s
From Proteopedia
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| - | + | ==Crystal structure of human mitochondrial mTERF in complex with a 15-mer DNA encompassing the tRNALeu(UUR) binding sequence== | |
| - | + | <StructureSection load='3n6s' size='340' side='right' caption='[[3n6s]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3n6s]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N6S FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n7q|3n7q]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n6s RCSB], [http://www.ebi.ac.uk/pdbsum/3n6s PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/3n6s_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain. | ||
| - | + | Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.,Jimenez-Menendez N, Fernandez-Millan P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernado P, Coll M, Uson I, Sola M Nat Struct Mol Biol. 2010 Jul;17(7):891-3. Epub 2010 Jun 13. PMID:20543826<ref>PMID:20543826</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arnan, C | + | [[Category: Arnan, C]] |
| - | [[Category: Bernado, P | + | [[Category: Bernado, P]] |
| - | [[Category: Coll, M | + | [[Category: Coll, M]] |
| - | [[Category: Fernandez-Millan, P | + | [[Category: Fernandez-Millan, P]] |
| - | [[Category: Jacobs, H T | + | [[Category: Jacobs, H T]] |
| - | [[Category: Jimenez-Menendez, N | + | [[Category: Jimenez-Menendez, N]] |
| - | [[Category: Montoya, J | + | [[Category: Montoya, J]] |
| - | [[Category: Rubio-Cosials, A | + | [[Category: Rubio-Cosials, A]] |
| - | [[Category: Sola, M | + | [[Category: Sola, M]] |
| - | [[Category: Uson, I | + | [[Category: Uson, I]] |
[[Category: Left-handed helical tandem repeat]] | [[Category: Left-handed helical tandem repeat]] | ||
[[Category: Mitochondrial replication pausing-dna complex]] | [[Category: Mitochondrial replication pausing-dna complex]] | ||
Revision as of 15:42, 18 December 2014
Crystal structure of human mitochondrial mTERF in complex with a 15-mer DNA encompassing the tRNALeu(UUR) binding sequence
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Categories: Homo sapiens | Arnan, C | Bernado, P | Coll, M | Fernandez-Millan, P | Jacobs, H T | Jimenez-Menendez, N | Montoya, J | Rubio-Cosials, A | Sola, M | Uson, I | Left-handed helical tandem repeat | Mitochondrial replication pausing-dna complex | Mitochondrial transcription termination factor-dna complex | Protein-dna complex | Replication-dna complex | Transcription
