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3ki7

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{{STRUCTURE_3ki7| PDB=3ki7 | SCENE= }}
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==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I==
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===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I===
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<StructureSection load='3ki7' size='340' side='right' caption='[[3ki7]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ki7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KI7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9I:2-{2-[4-(PYRROLIDIN-1-YLMETHYL)PHENYL]ETHYL}-5,6-DIHYDROIMIDAZO[4,5,1-JK][1,4]BENZODIAZEPIN-7(4H)-ONE'>G9I</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ess|3ess]], [[2q6m|2q6m]], [[2q5t|2q5t]], [[3ki0|3ki0]], [[3ki1|3ki1]], [[3ki2|3ki2]], [[3ki3|3ki3]], [[3ki4|3ki4]], [[3ki5|3ki5]], [[3ki6|3ki6]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki7 PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
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*[[Exotoxin|Exotoxin]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3ki7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI7 OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
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[[Category: Edwards, P R.]]
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[[Category: Edwards, P R]]
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[[Category: Jorgensen, R.]]
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[[Category: Jorgensen, R]]
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[[Category: Merrill, A R.]]
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[[Category: Merrill, A R]]
[[Category: Adp-ribosyl transferase]]
[[Category: Adp-ribosyl transferase]]
[[Category: Alpha-beta complex]]
[[Category: Alpha-beta complex]]

Revision as of 16:46, 18 December 2014

Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I

3ki7, resolution 1.32Å

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