3j0b

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{{STRUCTURE_3j0b| PDB=3j0b | SCENE= }}
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==cryo-EM reconstruction of West Nile virus==
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===cryo-EM reconstruction of West Nile virus===
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<StructureSection load='3j0b' size='340' side='right' caption='[[3j0b]], [[Resolution|resolution]] 10.30&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23602814}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j0b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Wnv Wnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J0B FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hg0|2hg0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j0b RCSB], [http://www.ebi.ac.uk/pdbsum/3j0b PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Coordinated interplay between membrane proteins and the lipid bilayer is required for such processes as transporter function and the entrance of enveloped viruses into host cells. In this study, three-dimensional cryo-electron microscopy density maps of mature and immature flaviviruses were analyzed to assess the curvature of the membrane leaflets and its relation to membrane-bound viral glycoproteins. The overall morphology of the viral membrane is determined by icosahedral scaffolding composed of envelope (E) and membrane (M) proteins through interaction of the proteins' stem-anchor regions with the membrane. In localized regions, small membrane regions exhibit convex, concave, flat or saddle-shaped surfaces that are constrained by the specific protein organization within each membrane leaflet. These results suggest that the organization of membrane proteins in small enveloped viruses mediate the formation of membrane curvature.
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==Function==
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Membrane curvature in flaviviruses.,Zhang W, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG J Struct Biol. 2013 Apr 18. pii: S1047-8477(13)00100-7. doi:, 10.1016/j.jsb.2013.04.005. PMID:23602814<ref>PMID:23602814</ref>
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[[http://www.uniprot.org/uniprot/Q9Q6P4_WNV Q9Q6P4_WNV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3j0b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J0B OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023602814</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: West nile virus]]
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</StructureSection>
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[[Category: Chipman, P R.]]
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[[Category: Wnv]]
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[[Category: Kaufmann, B.]]
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[[Category: Chipman, P R]]
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[[Category: Kuhn, R J.]]
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[[Category: Kaufmann, B]]
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[[Category: Rossmann, M G.]]
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[[Category: Kuhn, R J]]
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[[Category: Zhang, W.]]
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[[Category: Rossmann, M G]]
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[[Category: Zhang, W]]
[[Category: Virus]]
[[Category: Virus]]
[[Category: West nile virus]]
[[Category: West nile virus]]

Revision as of 16:51, 18 December 2014

cryo-EM reconstruction of West Nile virus

3j0b, resolution 10.30Å

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