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1qwf
From Proteopedia
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| - | [[Image:1qwf.jpg|left|200px]] | + | [[Image:1qwf.jpg|left|200px]] |
| - | + | ||
| - | '''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12''' | + | {{Structure |
| + | |PDB= 1qwf |SIZE=350|CAPTION= <scene name='initialview01'>1qwf</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] | ||
| + | |GENE= CHICKEN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11876 Avian sarcoma virus]) | ||
| + | }} | ||
| + | |||
| + | '''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QWF is a [ | + | 1QWF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWF OCA]. |
==Reference== | ==Reference== | ||
| - | Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:[http:// | + | Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8618911 8618911] |
[[Category: Avian sarcoma virus]] | [[Category: Avian sarcoma virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: src sh3 domain]] | [[Category: src sh3 domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:43:36 2008'' |
Revision as of 11:43, 20 March 2008
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| Gene: | CHICKEN (Avian sarcoma virus) | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12
Overview
Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) ligands and selected from biased phage display libraries were used to investigate interactions between a specificity pocket in the Src SH3 domain and ligant residues flanking the proline-rich core. The solution structures of c-Src SH3 complexed with these peptides were solved by NMR. In addition to proline-rich, polyproline type II helix-forming core, the class I and II ligands each possesses a flanking sequence that occupies a large pocket between the RT and n-Src loops of the SH3 domain. Structural and mutational analyses illustrate how the two classes of SH3 ligands exploit a specificity pocket on the receptor differently to increase binding affinity and specificity.
About this Structure
1QWF is a Single protein structure of sequence from Avian sarcoma virus. Full crystallographic information is available from OCA.
Reference
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:8618911
Page seeded by OCA on Thu Mar 20 13:43:36 2008
