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3q1c
From Proteopedia
(Difference between revisions)
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| - | + | ==Structure of EspG Protein== | |
| - | === | + | <StructureSection load='3q1c' size='340' side='right' caption='[[3q1c]], [[Resolution|resolution]] 1.60Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3q1c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127:h6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1C FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2348C_3970, E2348_C_3970, espG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=168807 Escherichia coli O127:H6])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1c RCSB], [http://www.ebi.ac.uk/pdbsum/3q1c PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacterial pathogens secrete effectors into their hosts that subvert host defenses and redirect host processes. EspG is a type three secretion effector with a disputed function that is found in enteropathogenic Escherichia coli. Here we show that EspG is structurally similar to VirA, a Shigella virulence factor; EspG has a large, conserved pocket on its surface; EspG binds directly to the amino-terminal inhibitory domain of human p21-activated kinase (PAK); and mutations to conserved residues in the surface pocket disrupt the interaction with PAK. | ||
| - | + | Structural and Functional Studies Indicate That the EPEC Effector, EspG, Directly Binds p21-Activated Kinase.,Germane KL, Spiller BW Biochemistry. 2011 Feb 15;50(6):917-9. Epub 2011 Jan 24. PMID:21235237<ref>PMID:21235237</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli o127:h6]] | [[Category: Escherichia coli o127:h6]] | ||
| - | [[Category: Germane, K L | + | [[Category: Germane, K L]] |
| - | [[Category: Spiller, B W | + | [[Category: Spiller, B W]] |
[[Category: P21 activated kinase]] | [[Category: P21 activated kinase]] | ||
[[Category: Pak recruitment and activation]] | [[Category: Pak recruitment and activation]] | ||
Revision as of 10:06, 19 December 2014
Structure of EspG Protein
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