1r2h

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[[Image:1r2h.gif|left|200px]]<br /><applet load="1r2h" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1r2h.gif|left|200px]]
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caption="1r2h, resolution 2.20&Aring;" />
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'''Human Bcl-XL containing an Ala to Leu mutation at position 142'''<br />
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{{Structure
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|PDB= 1r2h |SIZE=350|CAPTION= <scene name='initialview01'>1r2h</scene>, resolution 2.20&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= BCL-XL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Human Bcl-XL containing an Ala to Leu mutation at position 142'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1R2H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2H OCA].
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1R2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2H OCA].
==Reference==
==Reference==
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Bcl-XL mutations suppress cellular sensitivity to antimycin A., Manion MK, O'Neill JW, Giedt CD, Kim KM, Zhang KY, Hockenbery DM, J Biol Chem. 2004 Jan 16;279(3):2159-65. Epub 2003 Oct 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14534311 14534311]
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Bcl-XL mutations suppress cellular sensitivity to antimycin A., Manion MK, O'Neill JW, Giedt CD, Kim KM, Zhang KY, Hockenbery DM, J Biol Chem. 2004 Jan 16;279(3):2159-65. Epub 2003 Oct 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14534311 14534311]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: mutation]]
[[Category: mutation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:46:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:45:58 2008''

Revision as of 11:46, 20 March 2008

Image:1r2h.gif


PDB ID 1r2h

Drag the structure with the mouse to rotate
, resolution 2.20Å
Gene: BCL-XL (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Human Bcl-XL containing an Ala to Leu mutation at position 142


Overview

Cells expressing high levels of the BCL-X(L) anti-apoptotic protein are preferentially killed by the mitochondrial inhibitor antimycin A (AA). Computational modeling predicts a binding site for AA in the extended hydrophobic groove on BCL-X(L), previously identified as an interface for dimerization to BAX and related proapoptotic proteins. Here, we identify BCL-X(L) hydrophobic groove mutants with normal cellular anti-apoptotic function but suppressed sensitivity to AA. The LD(50) of AA for cells expressing BCL-X(L) mutants directly correlates with the measured in vitro dissociation constants for AA binding. These results indicate that BCL-X(L) is a principal target mediating AA cytotoxicity.

About this Structure

1R2H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Bcl-XL mutations suppress cellular sensitivity to antimycin A., Manion MK, O'Neill JW, Giedt CD, Kim KM, Zhang KY, Hockenbery DM, J Biol Chem. 2004 Jan 16;279(3):2159-65. Epub 2003 Oct 8. PMID:14534311

Page seeded by OCA on Thu Mar 20 13:45:58 2008

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