1r3g

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[[Image:1r3g.gif|left|200px]]<br /><applet load="1r3g" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1r3g.gif|left|200px]]
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caption="1r3g, resolution 1.16&Aring;" />
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'''1.16A X-ray structure of the synthetic DNA fragment with the incorporated 2'-O-[(2-Guanidinium)ethyl]-5-methyluridine residues'''<br />
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{{Structure
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|PDB= 1r3g |SIZE=350|CAPTION= <scene name='initialview01'>1r3g</scene>, resolution 1.16&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''1.16A X-ray structure of the synthetic DNA fragment with the incorporated 2'-O-[(2-Guanidinium)ethyl]-5-methyluridine residues'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1R3G is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3G OCA].
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1R3G is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3G OCA].
==Reference==
==Reference==
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2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures., Prakash TP, Puschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M, Org Lett. 2004 Jun 10;6(12):1971-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15176796 15176796]
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2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures., Prakash TP, Puschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M, Org Lett. 2004 Jun 10;6(12):1971-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15176796 15176796]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Egli, M.]]
[[Category: Egli, M.]]
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[[Category: dna]]
[[Category: dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:46:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:46:19 2008''

Revision as of 11:46, 20 March 2008

Image:1r3g.gif


PDB ID 1r3g

Drag the structure with the mouse to rotate
, resolution 1.16Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



1.16A X-ray structure of the synthetic DNA fragment with the incorporated 2'-O-[(2-Guanidinium)ethyl]-5-methyluridine residues


Overview

[structure: see text] Oligonucleotides with a novel 2'-O-[2-(guanidinium)ethyl] (2'-O-GE) modification have been synthesized using a novel protecting group strategy for the guanidinium group. This modification enhances the binding affinity of oligonucleotides to RNA as well as duplex DNA (DeltaT(m) 3.2 degrees C per modification). The 2'-O-GE modified oligonucleotides exhibited exceptional resistance to nuclease degradation. The crystal structure of a palindromic duplex formed by a DNA oligonucleotide with a single 2'-O-GE modification was solved at 1.16 A resolution.

About this Structure

1R3G is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures., Prakash TP, Puschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M, Org Lett. 2004 Jun 10;6(12):1971-4. PMID:15176796

Page seeded by OCA on Thu Mar 20 13:46:19 2008

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