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1r7r

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[[Image:1r7r.gif|left|200px]]<br /><applet load="1r7r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1r7r.gif|left|200px]]
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caption="1r7r, resolution 3.60&Aring;" />
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'''The crystal structure of murine p97/VCP at 3.6A'''<br />
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{{Structure
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|PDB= 1r7r |SIZE=350|CAPTION= <scene name='initialview01'>1r7r</scene>, resolution 3.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
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|ACTIVITY=
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|GENE= VCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''The crystal structure of murine p97/VCP at 3.6A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1R7R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1R7R with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7R OCA].
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1R7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1R7R with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7R OCA].
==Reference==
==Reference==
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The crystal structure of murine p97/VCP at 3.6A., Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS, J Struct Biol. 2003 Dec;144(3):337-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14643202 14643202]
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The crystal structure of murine p97/VCP at 3.6A., Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS, J Struct Biol. 2003 Dec;144(3):337-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14643202 14643202]
[[Category: AAA+ Proteases]]
[[Category: AAA+ Proteases]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: vcp]]
[[Category: vcp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:48:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:47:57 2008''

Revision as of 11:47, 20 March 2008

Image:1r7r.gif


PDB ID 1r7r

Drag the structure with the mouse to rotate
, resolution 3.60Å
Ligands:
Gene: VCP (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



The crystal structure of murine p97/VCP at 3.6A


Overview

p97/VCP is a member of the AAA ATPase family and has roles in both membrane fusion and ubiquitin dependent protein degradation. Here, we present a 3.6A crystal structure of murine p97 in which D2 domain has been modelled as poly-alanine and the remaining approximately 100 residues are absent. The resulting structure illustrates a head-to-tail packing arrangement of the two p97 AAA domains in a natural hexameric state with D1 ADP bound and D2 nucleotide free. The head-to-tail packing arrangement observed in this structure is in contrast to our previously predicted tail-to-tail packing model. The linker between the D1 and D2 domains is partially disordered, suggesting a flexible nature. Normal mode analysis of the crystal structure suggests anti-correlated motions and distinct conformational states of the two AAA domains.

About this Structure

1R7R is a Single protein structure of sequence from Mus musculus. The following page contains interesting information on the relation of 1R7R with [AAA+ Proteases]. Full crystallographic information is available from OCA.

Reference

The crystal structure of murine p97/VCP at 3.6A., Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS, J Struct Biol. 2003 Dec;144(3):337-48. PMID:14643202

Page seeded by OCA on Thu Mar 20 13:47:57 2008

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