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3vl1
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of yeast Rpn14== | |
| - | === | + | <StructureSection load='3vl1' size='340' side='right' caption='[[3vl1]], [[Resolution|resolution]] 1.60Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3vl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VL1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3acp|3acp]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RPN14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3vl1 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The 26S proteasome is an ATP-dependent protease responsible for selective degradation of polyubiquitylated proteins. Recent studies have suggested that proteasome assembly is a highly ordered multi-step process assisted by specific chaperones. Rpn14, an assembly chaperone for ATPase-ring formation, specifically recognizes the ATPase subunit Rpt6. The structure of Rpn14 at 2.0 A resolution in space group P6(4) has previously been reported, but the detailed mechanism of Rpn14 function remains unclear. Here, a new crystal structure of Rpn14 with an E384A mutation is presented in space group P2(1) at 1.6 A resolution. This high-resolution structure provides a framework for understanding proteasome assembly. | ||
| - | + | New crystal structure of the proteasome-dedicated chaperone Rpn14 at 1.6 A resolution.,Kim S, Nishide A, Saeki Y, Takagi K, Tanaka K, Kato K, Mizushima T Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 May 1;68(Pt 5):517-21., doi: 10.1107/S1744309112011359. Epub 2012 Apr 20. PMID:22691779<ref>PMID:22691779</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
==See Also== | ==See Also== | ||
*[[Proteasome|Proteasome]] | *[[Proteasome|Proteasome]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae s288c]] | [[Category: Saccharomyces cerevisiae s288c]] | ||
| - | [[Category: Kato, K | + | [[Category: Kato, K]] |
| - | [[Category: Kim, S | + | [[Category: Kim, S]] |
| - | [[Category: Mizushima, T | + | [[Category: Mizushima, T]] |
| - | [[Category: Nishide, A | + | [[Category: Nishide, A]] |
| - | [[Category: Saeki, Y | + | [[Category: Saeki, Y]] |
| - | [[Category: Takagi, K | + | [[Category: Takagi, K]] |
| - | [[Category: Tanaka, K | + | [[Category: Tanaka, K]] |
[[Category: Beta-propeller]] | [[Category: Beta-propeller]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Rpt6]] | [[Category: Rpt6]] | ||
Revision as of 06:42, 21 December 2014
Crystal structure of yeast Rpn14
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Categories: Saccharomyces cerevisiae s288c | Kato, K | Kim, S | Mizushima, T | Nishide, A | Saeki, Y | Takagi, K | Tanaka, K | Beta-propeller | Chaperone | Rpt6
