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4b7w
From Proteopedia
(Difference between revisions)
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| - | + | ==Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form== | |
| - | + | <StructureSection load='4b7w' size='340' side='right' caption='[[4b7w]], [[Resolution|resolution]] 4.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[4b7w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7W FirstGlance]. <br> |
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pzl|1pzl]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b7w RCSB], [http://www.ebi.ac.uk/pdbsum/4b7w PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:[http://omim.org/entry/125850 125850]]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:9313765</ref> <ref>PMID:9243109</ref> <ref>PMID:9449683</ref> | [[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:[http://omim.org/entry/125850 125850]]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:9313765</ref> <ref>PMID:9243109</ref> <ref>PMID:9449683</ref> | ||
| - | + | == Function == | |
| - | ==Function== | + | |
[[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine. | [[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine. | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | <references | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Barath, P | + | [[Category: Barath, P]] |
| - | [[Category: Dudasova, Z | + | [[Category: Dudasova, Z]] |
| - | [[Category: Kretova, M | + | [[Category: Kretova, M]] |
| - | [[Category: LeGuevel, R | + | [[Category: LeGuevel, R]] |
| - | [[Category: Leonard, G | + | [[Category: Leonard, G]] |
| - | [[Category: McSweeney, S | + | [[Category: McSweeney, S]] |
| - | [[Category: Okvist, M | + | [[Category: Okvist, M]] |
| - | [[Category: Ondrovicova, G | + | [[Category: Ondrovicova, G]] |
| - | [[Category: Salbert, G | + | [[Category: Salbert, G]] |
| - | [[Category: Skrabana, R | + | [[Category: Skrabana, R]] |
[[Category: Nuclear receptor]] | [[Category: Nuclear receptor]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
Revision as of 09:35, 21 December 2014
Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form
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