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4fpp
From Proteopedia
(Difference between revisions)
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| - | + | ==Bacterial phosphotransferase== | |
| - | === | + | <StructureSection load='4fpp' size='340' side='right' caption='[[4fpp]], [[Resolution|resolution]] 2.20Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4fpp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_crescentus_cb15 Caulobacter crescentus cb15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FPP FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CC_3470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=190650 Caulobacter crescentus CB15])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fpp RCSB], [http://www.ebi.ac.uk/pdbsum/4fpp PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Two-component and phosphorelay signal-transduction proteins are crucial for bacterial cell-cycle regulation in Caulobacter crescentus. ChpT is an essential histidine phosphotransferase that controls the activity of the master cell-cycle regulator CtrA by phosphorylation. Here, the 2.2 A resolution crystal structure of ChpT is reported. ChpT is a homodimer and adopts the domain architecture of the intracellular part of class I histidine kinases. Each subunit consists of two distinct domains: an N-terminal helical hairpin domain and a C-terminal alpha/beta domain. The two N-terminal domains are adjacent within the dimer, forming a four-helix bundle. The ChpT C-terminal domain adopts an atypical Bergerat ATP-binding fold. | ||
| - | + | Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle in Caulobacter crescentus.,Fioravanti A, Clantin B, Dewitte F, Lens Z, Verger A, Biondi EG, Villeret V Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Sep 1;68(Pt 9):1025-9., doi: 10.1107/S1744309112033064. Epub 2012 Aug 29. PMID:22949187<ref>PMID:22949187</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Phosphotransferase|Phosphotransferase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Caulobacter crescentus cb15]] | [[Category: Caulobacter crescentus cb15]] | ||
| - | [[Category: Biondi, E | + | [[Category: Biondi, E]] |
| - | [[Category: Clantin, B | + | [[Category: Clantin, B]] |
| - | [[Category: Dewitte, F | + | [[Category: Dewitte, F]] |
| - | [[Category: Fioravanti, A | + | [[Category: Fioravanti, A]] |
| - | [[Category: Lens, Z | + | [[Category: Lens, Z]] |
| - | [[Category: Verger, A | + | [[Category: Verger, A]] |
| - | [[Category: Villeret, V | + | [[Category: Villeret, V]] |
[[Category: Bacterial cytoplasme]] | [[Category: Bacterial cytoplasme]] | ||
[[Category: Bergerat fold]] | [[Category: Bergerat fold]] | ||
Revision as of 10:46, 21 December 2014
Bacterial phosphotransferase
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