1rv0
From Proteopedia
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| - | [[Image:1rv0.gif|left|200px]] | + | [[Image:1rv0.gif|left|200px]] |
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| - | '''1930 Swine H1 Hemagglutinin complexed with LSTA''' | + | {{Structure |
| + | |PDB= 1rv0 |SIZE=350|CAPTION= <scene name='initialview01'>1rv0</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID'>DAN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''1930 Swine H1 Hemagglutinin complexed with LSTA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RV0 is a [ | + | 1RV0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV0 OCA]. |
==Reference== | ==Reference== | ||
| - | The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:[http:// | + | The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14764886 14764886] |
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: influenza a virus]] | [[Category: influenza a virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:56:35 2008'' |
Revision as of 11:56, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
1930 Swine H1 Hemagglutinin complexed with LSTA
Overview
The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
About this Structure
1RV0 is a Protein complex structure of sequences from Influenza a virus. Full crystallographic information is available from OCA.
Reference
The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886
Page seeded by OCA on Thu Mar 20 13:56:35 2008
