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4gmi

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{{STRUCTURE_4gmi| PDB=4gmi | SCENE= }}
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==BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571==
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===BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571===
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<StructureSection load='4gmi' size='340' side='right' caption='[[4gmi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XA:(4S,8E)-4-[(1R)-2-{[2-(5-TERT-BUTYL-1,3-OXAZOL-2-YL)PROPAN-2-YL]AMINO}-1-HYDROXYETHYL]-16-METHYL-6-OXA-3-AZABICYCLO[12.3.1]OCTADECA-1(18),8,14,16-TETRAENE-2,13-DIONE'>0XA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dpf|4dpf]], [[4dpi|4dpi]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmi RCSB], [http://www.ebi.ac.uk/pdbsum/4gmi PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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*[[Beta secretase|Beta secretase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4gmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMI OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
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[[Category: Derbyshire, D.]]
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[[Category: Derbyshire, D]]
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[[Category: Lindberg, J D.]]
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[[Category: Lindberg, J D]]
[[Category: Asp2]]
[[Category: Asp2]]
[[Category: Bace]]
[[Category: Bace]]

Revision as of 11:36, 21 December 2014

BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571

4gmi, resolution 1.80Å

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