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4klz
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis== |
| - | + | <StructureSection load='4klz' size='340' side='right' caption='[[4klz]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4klz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5p21|5p21]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klz RCSB], [http://www.ebi.ac.uk/pdbsum/4klz PDBsum]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN]] Noonan syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN]] Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.<ref>PMID:15632082</ref> <ref>PMID:23791108</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ab, E]] | ||
| + | [[Category: Andrews, M]] | ||
| + | [[Category: Hoedemaeker, F J]] | ||
| + | [[Category: Keizers, P H]] | ||
| + | [[Category: Kobayashi, M]] | ||
| + | [[Category: Manning, L]] | ||
| + | [[Category: Rzepiela, A A]] | ||
| + | [[Category: Shah, D M]] | ||
| + | [[Category: Siegal, G]] | ||
| + | [[Category: Tuin, A W]] | ||
| + | [[Category: Gdp/gtp binding]] | ||
| + | [[Category: Guanine nucleotide binding]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Small gtpase]] | ||
Revision as of 14:40, 21 December 2014
Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
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