1sd5
From Proteopedia
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| - | [[Image:1sd5.gif|left|200px]] | + | [[Image:1sd5.gif|left|200px]] |
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| - | '''Crystal structure of Rv1626''' | + | {{Structure |
| + | |PDB= 1sd5 |SIZE=350|CAPTION= <scene name='initialview01'>1sd5</scene>, resolution 1.68Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= rv1626 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of Rv1626''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SD5 is a [ | + | 1SD5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SD5 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:[http:// | + | The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341725 15341725] |
[[Category: Mycobacterium tuberculosis h37rv]] | [[Category: Mycobacterium tuberculosis h37rv]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: psi]] | [[Category: psi]] | ||
[[Category: rv1626]] | [[Category: rv1626]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: tb structural genomics consortium]] | [[Category: tb structural genomics consortium]] | ||
[[Category: tbsgc]] | [[Category: tbsgc]] | ||
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[[Category: two components system]] | [[Category: two components system]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:03:24 2008'' |
Revision as of 12:03, 20 March 2008
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| , resolution 1.68Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | rv1626 (Mycobacterium tuberculosis H37Rv) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Rv1626
Overview
We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems. The C-terminal domain has high structural homology to a recently discovered RNA binding domain involved in transcriptional antitermination. The molecule in solution was found to be monomeric as it is in the crystal, but in solution it undergoes a conformational change that is triggered by changes in ionic strength. This is the first structure that links the phosphorylation cascade of the two-component systems with the antitermination event in the transcriptional machinery. Rv1626 belongs to a family of proteins, which we propose calling phosphorylation-dependent transcriptional antitermination regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.
About this Structure
1SD5 is a Single protein structure of sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:15341725
Page seeded by OCA on Thu Mar 20 14:03:24 2008
Categories: Mycobacterium tuberculosis h37rv | Single protein | Feng, V. | Morth, J P. | Perry, L J. | Svergun, D I. | TBSGC, TB Structural Genomics Consortium. | Tucker, P A. | IOD | Antiterminator | Protein structure initiative | Psi | Rv1626 | Structural genomic | Tb structural genomics consortium | Tbsgc | Transcriptional | Two components system
