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2mgn
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3== | |
| - | + | <StructureSection load='2mgn' size='340' side='right' caption='[[2mgn]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2mgn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MGN FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PQ3:N2,N9-BIS(1-METHYLQUINOLIN-3-YL)-1,10-PHENANTHROLINE-2,9-DICARBOXAMIDE'>PQ3</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mgn RCSB], [http://www.ebi.ac.uk/pdbsum/2mgn PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive pi-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation. | ||
| - | + | Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.,Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977<ref>PMID:24356977</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Chung, W J | + | == References == |
| - | [[Category: Hamon, F | + | <references/> |
| - | [[Category: Heddi, B | + | __TOC__ |
| - | [[Category: Phan, A T | + | </StructureSection> |
| - | [[Category: Teulade-Fichou, M P | + | [[Category: Chung, W J]] |
| + | [[Category: Hamon, F]] | ||
| + | [[Category: Heddi, B]] | ||
| + | [[Category: Phan, A T]] | ||
| + | [[Category: Teulade-Fichou, M P]] | ||
[[Category: C-myc promoter]] | [[Category: C-myc promoter]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: Ligand]] | [[Category: Ligand]] | ||
Revision as of 16:34, 21 December 2014
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3
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Categories: Chung, W J | Hamon, F | Heddi, B | Phan, A T | Teulade-Fichou, M P | C-myc promoter | Dna | Ligand
