This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4lg8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4lg8| PDB=4lg8 | SCENE= }}
+
==Crystal structure of PRPF19 WD40 repeats==
-
===Crystal structure of PRPF19 WD40 repeats===
+
<StructureSection load='4lg8' size='340' side='right' caption='[[4lg8]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[4lg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG8 FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/PRP19_HUMAN PRP19_HUMAN]] Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.<ref>PMID:11082287</ref> <ref>PMID:12960389</ref> <ref>PMID:16332694</ref> <ref>PMID:15660529</ref> <ref>PMID:16223718</ref> <ref>PMID:16388800</ref>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-
 
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRPF19, NMP200, PRP19, SNEV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg8 PDBsum]</span></td></tr>
-
[[4lg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG8 OCA].
+
</table>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<references group="xtra"/><references/>
+
[[Category: Human]]
[[Category: Human]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith, C H]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra, C]]
-
[[Category: Dobrovetsky, E.]]
+
[[Category: Dobrovetsky, E]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards, A M]]
-
[[Category: He, H.]]
+
[[Category: He, H]]
-
[[Category: Min, J.]]
+
[[Category: Min, J]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Structural genomic]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel, W]]
-
[[Category: Xu, C.]]
+
[[Category: Xu, C]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Sgc]]
[[Category: Sgc]]
-
[[Category: Structural genomics consortium]]
 
[[Category: Wd40 repeat]]
[[Category: Wd40 repeat]]

Revision as of 18:58, 21 December 2014

Crystal structure of PRPF19 WD40 repeats

4lg8, resolution 1.89Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lg8"
Personal tools