1tp4
From Proteopedia
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| - | [[Image:1tp4.gif|left|200px]] | + | [[Image:1tp4.gif|left|200px]] |
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| - | '''Solution structure of the XPC binding domain of hHR23A protein''' | + | {{Structure |
| + | |PDB= 1tp4 |SIZE=350|CAPTION= <scene name='initialview01'>1tp4</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= RAD23A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of the XPC binding domain of hHR23A protein''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TP4 is a [ | + | 1TP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TP4 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction., Kamionka M, Feigon J, Protein Sci. 2004 Sep;13(9):2370-7. PMID:[http:// | + | Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction., Kamionka M, Feigon J, Protein Sci. 2004 Sep;13(9):2370-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15322280 15322280] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: xpc]] | [[Category: xpc]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:21:19 2008'' |
Revision as of 12:21, 20 March 2008
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| Gene: | RAD23A (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the XPC binding domain of hHR23A protein
Overview
Rad23 proteins are involved both in the ubiquitin-proteasome pathway and in nucleotide excision repair (NER), but the relationship between these two pathways is not yet understood. The two human homologs of Rad23, hHR23A and B, are functionally redundant in NER and interact with xeroderma pigmentosum complementation group C (XPC) protein. The XPC-hHR23 complex is responsible for the specific recognition of damaged DNA, which is an early step in NER. The interaction of the XPC binding domain (XPCB) of hHR23A/B with XPC protein has been shown to be important for its optimal function in NER. We have determined the solution structure of XPCB of hHR23A. The domain consists of five amphipathic helices and reveals hydrophobic patches on the otherwise highly hydrophilic domain surface. The patches are predicted to be involved in interaction with XPC. The XPCB domain has limited sequence homology with any proteins outside of the Rad23 family except for sacsin, a protein involved in spastic ataxia of Charlevoix-Saguenay, which contains a domain with 35% sequence identity.
About this Structure
1TP4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction., Kamionka M, Feigon J, Protein Sci. 2004 Sep;13(9):2370-7. PMID:15322280
Page seeded by OCA on Thu Mar 20 14:21:19 2008
Categories: Homo sapiens | Single protein | Feigon, J. | Kamionka, M. | Dna repair | Ner | Rad23 | Xpc
