1u5r

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[[Image:1u5r.gif|left|200px]]<br /><applet load="1u5r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1u5r.gif|left|200px]]
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caption="1u5r, resolution 2.1&Aring;" />
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'''Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K'''<br />
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{{Structure
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|PDB= 1u5r |SIZE=350|CAPTION= <scene name='initialview01'>1u5r</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene>
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|ACTIVITY=
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|GENE= serine/threonine protein kinase TAO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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}}
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'''Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1U5R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5R OCA].
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1U5R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5R OCA].
==Reference==
==Reference==
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Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K., Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ, Structure. 2004 Oct;12(10):1891-900. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15458637 15458637]
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Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K., Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ, Structure. 2004 Oct;12(10):1891-900. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15458637 15458637]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: serine/threonine protein kinase]]
[[Category: serine/threonine protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:20:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:27:36 2008''

Revision as of 12:27, 20 March 2008

Image:1u5r.gif


PDB ID 1u5r

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands: , and
Gene: serine/threonine protein kinase TAO2 (Rattus norvegicus)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K


Overview

TAO2 is a mitogen-activated protein kinase kinase kinase (MAP3K) that doubly phosphorylates and activates the MAP kinase kinases (MAP2Ks) MEK3 and MEK6. The structure of the kinase domain of TAO2 (1-320) has been solved in its phosphorylated active conformation. The structure, together with structure-based mutagenic analysis, reveals that positively charged residues in the substrate binding groove mediate the first step in the dual phosphorylation of MEK6, on the threonine residue in the motif DS*VAKT*I (*denotes phosphorylation site) of MEK6. TAO2 is a Ste20p homolog, and the structure of active TAO2, in comparison with that of low-activity p21-activated protein kinase (PAK1), a Ste20p-related MAP4K, reveals how this group of kinases is activated by phosphorylation. Finally, active TAO2 displays unusual interactions with ATP, involving, in part, a subgroup-specific C-terminal extension of TAO2. The observed interactions may be useful in making specific inhibitors of TAO kinases.

About this Structure

1U5R is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K., Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ, Structure. 2004 Oct;12(10):1891-900. PMID:15458637

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