1v6r
From Proteopedia
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| - | [[Image:1v6r.jpg|left|200px]] | + | [[Image:1v6r.jpg|left|200px]] |
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| - | '''Solution Structure of Endothelin-1 with its C-terminal Folding''' | + | {{Structure |
| + | |PDB= 1v6r |SIZE=350|CAPTION= <scene name='initialview01'>1v6r</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution Structure of Endothelin-1 with its C-terminal Folding''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1V6R is a [ | + | 1V6R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6R OCA]. |
==Reference== | ==Reference== | ||
| - | Distributed computing and NMR constraint-based high-resolution structure determination: applied for bioactive Peptide endothelin-1 to determine C-terminal folding., Takashima H, Mimura N, Ohkubo T, Yoshida T, Tamaoki H, Kobayashi Y, J Am Chem Soc. 2004 Apr 14;126(14):4504-5. PMID:[http:// | + | Distributed computing and NMR constraint-based high-resolution structure determination: applied for bioactive Peptide endothelin-1 to determine C-terminal folding., Takashima H, Mimura N, Ohkubo T, Yoshida T, Tamaoki H, Kobayashi Y, J Am Chem Soc. 2004 Apr 14;126(14):4504-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15070353 15070353] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kobayashi, Y.]] | [[Category: Kobayashi, Y.]] | ||
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[[Category: g-protein coupled-receptor ligand]] | [[Category: g-protein coupled-receptor ligand]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:41:31 2008'' |
Revision as of 12:41, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of Endothelin-1 with its C-terminal Folding
Contents |
Overview
Distributed computing has been implemented to the solution structure determination of endothelin-1 to evaluate efficiency of the method for NMR constraint-based structure calculations. A key target of the investigation was determination of the C-terminal folding of the peptide, which had been dispersed in previous studies of NMR, despite its pharmacological significances. With use of tens of thousands of random initial structures to explore the conformational space comprehensively, we determined high-resolution structures with good convergences of C-terminal as well as previously defined N-terminal structures. The previous studies had missed the C-terminal convergence because of initial structure dependencies trapped in localized folding of the N-terminal region, which are strongly constricted by two disulfide bonds.
Disease
Known disease associated with this structure: High density lipoprotein cholesterol level QTL 7 OMIM:[131240]
About this Structure
1V6R is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Distributed computing and NMR constraint-based high-resolution structure determination: applied for bioactive Peptide endothelin-1 to determine C-terminal folding., Takashima H, Mimura N, Ohkubo T, Yoshida T, Tamaoki H, Kobayashi Y, J Am Chem Soc. 2004 Apr 14;126(14):4504-5. PMID:15070353
Page seeded by OCA on Thu Mar 20 14:41:31 2008
