1v9u
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1v9u.gif|left|200px]] | + | [[Image:1v9u.gif|left|200px]] |
| - | + | ||
| - | '''Human Rhinovirus 2 bound to a fragment of its cellular receptor protein''' | + | {{Structure |
| + | |PDB= 1v9u |SIZE=350|CAPTION= <scene name='initialview01'>1v9u</scene>, resolution 3.6Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=DAO:LAURIC ACID'>DAO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Human Rhinovirus 2 bound to a fragment of its cellular receptor protein''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 10: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1V9U is a [ | + | 1V9U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_rhinovirus_2 Human rhinovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V9U OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein., Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D, Nat Struct Mol Biol. 2004 May;11(5):429-34. Epub 2004 Apr 4. PMID:[http:// | + | X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein., Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D, Nat Struct Mol Biol. 2004 May;11(5):429-34. Epub 2004 Apr 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15064754 15064754] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human rhinovirus 2]] | [[Category: Human rhinovirus 2]] | ||
| Line 29: | Line 38: | ||
[[Category: vldl-receptor]] | [[Category: vldl-receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:42:41 2008'' |
Revision as of 12:42, 20 March 2008
| |||||||
| , resolution 3.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Human Rhinovirus 2 bound to a fragment of its cellular receptor protein
Contents |
Overview
Although many viral receptors have been identified, the ways in which they interact with their cognate viruses are not understood at the molecular level. We have determined the X-ray structure of a complex between calcium-containing modules of the very low-density lipoprotein receptor and the minor group human rhinovirus HRV2. The receptor binds close to the icosahedral five-fold vertex, with only one module per virus protomer. The binding face of this module is defined by acidic calcium-chelating residues and, in particular, by an exposed tryptophan that is highly conserved. The attachment site on the virus involves only residues from VP1, particularly a lysine strictly conserved in all minor group HRVs. The disposition of the attached ligand-binding repeats around the five-fold axis, together with the proximity of the N- and C-terminal ends of adjacent modules, suggests that more than one repeat in a single receptor molecule might attach simultaneously.
Disease
Known disease associated with this structure: Cerebellar hypoplasia, VLDLR-associated OMIM:[192977]
About this Structure
1V9U is a Protein complex structure of sequences from Homo sapiens and Human rhinovirus 2. Full crystallographic information is available from OCA.
Reference
X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein., Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D, Nat Struct Mol Biol. 2004 May;11(5):429-34. Epub 2004 Apr 4. PMID:15064754
Page seeded by OCA on Thu Mar 20 14:42:41 2008
