1vdf
From Proteopedia
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| - | [[Image:1vdf.gif|left|200px]] | + | [[Image:1vdf.gif|left|200px]] |
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| - | '''ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN''' | + | {{Structure |
| + | |PDB= 1vdf |SIZE=350|CAPTION= <scene name='initialview01'>1vdf</scene>, resolution 2.05Å | ||
| + | |SITE= <scene name='pdbsite=ION:Binds+Cl-'>ION</scene> | ||
| + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1VDF is a [ | + | 1VDF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDF OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?, Malashkevich VN, Kammerer RA, Efimov VP, Schulthess T, Engel J, Science. 1996 Nov 1;274(5288):761-5. PMID:[http:// | + | The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?, Malashkevich VN, Kammerer RA, Efimov VP, Schulthess T, Engel J, Science. 1996 Nov 1;274(5288):761-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8864111 8864111] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oligomeric matrix protein]] | [[Category: oligomeric matrix protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:44:06 2008'' |
Revision as of 12:44, 20 March 2008
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| , resolution 2.05Å | |||||||
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| Sites: | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN
Overview
Oligomerization by the formation of alpha-helical bundles is common in many proteins. The crystal structure of a parallel pentameric coiled coil, constituting the oligomerization domain in the cartilage oligomeric matrix protein (COMP), was determined at 2.05 angstroms resolution. The same structure probably occurs in two other extracellular matrix proteins, thrombospondins 3 and 4. Complementary hydrophobic interactions and conserved disulfide bridges between the alpha helices result in a thermostable structure with unusual properties. The long hydrophobic axial pore is filled with water molecules but can also accommodate small apolar groups. An "ion trap" is formed inside the pore by a ring of conserved glutamines, which binds chloride and probably other monatomic anions. The oligomerization domain of COMP has marked similarities with proposed models of the pentameric transmembrane ion channels in phospholamban and the acetylcholine receptor.
About this Structure
1VDF is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?, Malashkevich VN, Kammerer RA, Efimov VP, Schulthess T, Engel J, Science. 1996 Nov 1;274(5288):761-5. PMID:8864111
Page seeded by OCA on Thu Mar 20 14:44:06 2008
