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2chm
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2chm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHM FirstGlance]. <br> | <table><tr><td colspan='2'>[[2chm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3P4:5-[2-(BUT-3-EN-1-YLOXY)-5-(1-HYDROXYVINYL)PYRIDIN-3-YL]-3-ETHYL-2-(1-ETHYLAZETIDIN-3-YL)-1,2,6,7A-TETRAHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE'>3P4</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3P4:5-[2-(BUT-3-EN-1-YLOXY)-5-(1-HYDROXYVINYL)PYRIDIN-3-YL]-3-ETHYL-2-(1-ETHYLAZETIDIN-3-YL)-1,2,6,7A-TETRAHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE'>3P4</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f0j|1f0j]], [[1jp1|1jp1]], [[1jp2|1jp2]], [[1ro6|1ro6]], [[1ro9|1ro9]], [[1ror|1ror]], [[1rkp|1rkp]], [[1t9r|1t9r]], [[1t9s|1t9s]], [[1tb5|1tb5]], [[1tbf|1tbf]], [[1udt|1udt]], [[1udu|1udu]], [[1uho|1uho]], [[1xlx|1xlx]], [[1xlz|1xlz]], [[1xm4|1xm4]], [[1xm6|1xm6]], [[1xmu|1xmu]], [[1xmy|1xmy]], [[1xn0|1xn0]], [[1xos|1xos]], [[1xot|1xot]], [[1xoz|1xoz]], [[1xp0|1xp0]], [[1y2h|1y2h]], [[1y2j|1y2j]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f0j|1f0j]], [[1jp1|1jp1]], [[1jp2|1jp2]], [[1ro6|1ro6]], [[1ro9|1ro9]], [[1ror|1ror]], [[1rkp|1rkp]], [[1t9r|1t9r]], [[1t9s|1t9s]], [[1tb5|1tb5]], [[1tbf|1tbf]], [[1udt|1udt]], [[1udu|1udu]], [[1uho|1uho]], [[1xlx|1xlx]], [[1xlz|1xlz]], [[1xm4|1xm4]], [[1xm6|1xm6]], [[1xmu|1xmu]], [[1xmy|1xmy]], [[1xn0|1xn0]], [[1xos|1xos]], [[1xot|1xot]], [[1xoz|1xoz]], [[1xp0|1xp0]], [[1y2h|1y2h]], [[1y2j|1y2j]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2chm RCSB], [http://www.ebi.ac.uk/pdbsum/2chm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2chm RCSB], [http://www.ebi.ac.uk/pdbsum/2chm PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Allerton, C M.N | + | [[Category: Allerton, C M.N]] |
| - | [[Category: Barber, C G | + | [[Category: Barber, C G]] |
| - | [[Category: Beaumont, K C | + | [[Category: Beaumont, K C]] |
| - | [[Category: Brown, D G | + | [[Category: Brown, D G]] |
| - | [[Category: Cole, S M | + | [[Category: Cole, S M]] |
| - | [[Category: Ellis, D | + | [[Category: Ellis, D]] |
| - | [[Category: Lane, C A.L | + | [[Category: Lane, C A.L]] |
| - | [[Category: Maw, G N | + | [[Category: Maw, G N]] |
| - | [[Category: Mount, N M | + | [[Category: Mount, N M]] |
| - | [[Category: Rawson, D J | + | [[Category: Rawson, D J]] |
| - | [[Category: Robinson, C M | + | [[Category: Robinson, C M]] |
| - | [[Category: Street, S D.A | + | [[Category: Street, S D.A]] |
| - | [[Category: Summerhill, N W | + | [[Category: Summerhill, N W]] |
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
[[Category: Camp]] | [[Category: Camp]] | ||
Revision as of 06:48, 24 December 2014
CRYSTAL STRUCTURE OF N2 SUBSTITUTED PYRAZOLO PYRIMIDINONES-A FLIPPED BINDING MODE IN PDE5
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Categories: Homo sapiens | Allerton, C M.N | Barber, C G | Beaumont, K C | Brown, D G | Cole, S M | Ellis, D | Lane, C A.L | Maw, G N | Mount, N M | Rawson, D J | Robinson, C M | Street, S D.A | Summerhill, N W | Allosteric enzyme | Camp | Cgmp | Cgmp-binding | Chimera | Hydrolase | Inhibitor | Magnesium | Metal-binding | Nucleotide-binding | Phosphodiesterase 5 | Phosphorylation
