1run
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1run]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUN FirstGlance]. <br> | <table><tr><td colspan='2'>[[1run]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUN FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1run FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1run OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1run RCSB], [http://www.ebi.ac.uk/pdbsum/1run PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1run FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1run OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1run RCSB], [http://www.ebi.ac.uk/pdbsum/1run PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Catabolite gene activator protein|Catabolite gene activator protein]] | *[[Catabolite gene activator protein|Catabolite gene activator protein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Berman, H M | + | [[Category: Berman, H M]] |
| - | [[Category: Ebright, R H | + | [[Category: Ebright, R H]] |
| - | [[Category: Gunasekera, A | + | [[Category: Gunasekera, A]] |
| - | [[Category: Kunkel, T A | + | [[Category: Kunkel, T A]] |
| - | [[Category: Parkinson, G N | + | [[Category: Parkinson, G N]] |
| - | [[Category: Vojtechovsky, J | + | [[Category: Vojtechovsky, J]] |
| - | [[Category: Zhang, X | + | [[Category: Zhang, X]] |
[[Category: 3d-structure]] | [[Category: 3d-structure]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
Revision as of 07:15, 24 December 2014
CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
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