This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3bu0
From Proteopedia
(Difference between revisions)
| Line 9: | Line 9: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bu0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bu0 RCSB], [http://www.ebi.ac.uk/pdbsum/3bu0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bu0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bu0 RCSB], [http://www.ebi.ac.uk/pdbsum/3bu0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 35: | Line 37: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: He, C | + | [[Category: He, C]] |
| - | [[Category: Yang, C G | + | [[Category: Yang, C G]] |
| - | [[Category: Yi, C | + | [[Category: Yi, C]] |
[[Category: Cross-link]] | [[Category: Cross-link]] | ||
[[Category: Dna damage]] | [[Category: Dna damage]] | ||
Revision as of 07:45, 24 December 2014
crystal structure of human ABH2 cross-linked to dsDNA with cofactors
| |||||||||||
