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4wj7

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'''Unreleased structure'''
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==CCM2 PTB domain in complex with KRIT1 NPxY/F3==
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<StructureSection load='4wj7' size='340' side='right' caption='[[4wj7]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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The entry 4wj7 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wj7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WJ7 FirstGlance]. <br>
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Authors: Fisher, O.S., Liu, W., Zhang, R., Stiegler, A.L., Boggon, T.J.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wj7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wj7 PDBsum]</span></td></tr>
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</table>
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Description:
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== Disease ==
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[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Boggon, T J]]
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[[Category: Fisher, O S]]
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[[Category: Liu, W]]
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[[Category: Stiegler, A L]]
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[[Category: Zhang, R]]
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[[Category: Complex]]
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[[Category: Npxy motif]]
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[[Category: Ptb domain]]

Revision as of 11:15, 24 December 2014

CCM2 PTB domain in complex with KRIT1 NPxY/F3

4wj7, resolution 2.75Å

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