1wlj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wlj.jpg|left|200px]]<br /><applet load="1wlj" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1wlj.jpg|left|200px]]
-
caption="1wlj, resolution 1.9&Aring;" />
+
 
-
'''human ISG20'''<br />
+
{{Structure
 +
|PDB= 1wlj |SIZE=350|CAPTION= <scene name='initialview01'>1wlj</scene>, resolution 1.9&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=U5P:URIDINE-5'-MONOPHOSPHATE'>U5P</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''human ISG20'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1WLJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=U5P:'>U5P</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLJ OCA].
+
1WLJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLJ OCA].
==Reference==
==Reference==
-
Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease., Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T, FEBS Lett. 2004 Nov 5;577(1-2):111-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15527770 15527770]
+
Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease., Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T, FEBS Lett. 2004 Nov 5;577(1-2):111-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15527770 15527770]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 24: Line 33:
[[Category: exoribonuclease]]
[[Category: exoribonuclease]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:45:40 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:58:31 2008''

Revision as of 12:58, 20 March 2008

Image:1wlj.jpg


PDB ID 1wlj

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



human ISG20


Overview

ISG20 is an interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. It belongs to the DEDDh group of RNases of the DEDD exonuclease superfamily. We have solved the crystal structure of human ISG20 complexed with two Mn2+ ions and uridine 5'-monophosphate (UMP) at 1.9 A resolution. Its structure, including that of the active site, is very similar to those of the corresponding domains of two DEDDh-group DNases, the epsilon subunit of Escherichia coli DNA polymerase III and E. coli exonuclease I, strongly suggesting that its catalytic mechanism is identical to that of the two DNases. However, ISG20 also has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2'-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates.

About this Structure

1WLJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease., Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T, FEBS Lett. 2004 Nov 5;577(1-2):111-6. PMID:15527770

Page seeded by OCA on Thu Mar 20 14:58:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wlj"
Personal tools