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4k6h

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<StructureSection load='4k6h' size='340' side='right' caption='[[4k6h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4k6h' size='340' side='right' caption='[[4k6h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4k6h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canar Canar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6H OCA]. <br>
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<table><tr><td colspan='2'>[[4k6h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canar Canar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K6H FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k5q|4k5q]], [[4k6g|4k6g]], [[4k6k|4k6k]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k5q|4k5q]], [[4k6g|4k6g]], [[4k6k|4k6k]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k6h RCSB], [http://www.ebi.ac.uk/pdbsum/4k6h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k6h RCSB], [http://www.ebi.ac.uk/pdbsum/4k6h PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LIPB_CANAR LIPB_CANAR]] Hydrolysis of triglycerides. Is very stereospecific both in hydrolysis and in organic synthesis and has a potentially important application in glucolipid synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Enhanced enzyme kinetic stability by increasing rigidity within the active site.,Xie Y, An J, Yang G, Wu G, Zhang Y, Cui L, Feng Y J Biol Chem. 2014 Mar 14;289(11):7994-8006. doi: 10.1074/jbc.M113.536045. Epub, 2014 Jan 21. PMID:24448805<ref>PMID:24448805</ref>
Enhanced enzyme kinetic stability by increasing rigidity within the active site.,Xie Y, An J, Yang G, Wu G, Zhang Y, Cui L, Feng Y J Biol Chem. 2014 Mar 14;289(11):7994-8006. doi: 10.1074/jbc.M113.536045. Epub, 2014 Jan 21. PMID:24448805<ref>PMID:24448805</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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==See Also==
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*[[Lipase|Lipase]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Canar]]
[[Category: Canar]]
[[Category: Triacylglycerol lipase]]
[[Category: Triacylglycerol lipase]]
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[[Category: An, J.]]
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[[Category: An, J]]
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[[Category: Feng, Y.]]
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[[Category: Feng, Y]]
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[[Category: Wu, G.]]
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[[Category: Wu, G]]
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[[Category: Xie, Y.]]
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[[Category: Xie, Y]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Lipase]]
[[Category: Lipase]]

Revision as of 13:56, 24 December 2014

Crystal structure of CALB mutant L278M from Candida antarctica

4k6h, resolution 1.60Å

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